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The latest anti-aging treatment that tightens the jowls. The Nefertiti neck lift is a new technique where by placing Botox injection along the lower jawline as well as down the side of the neck along the platysma muscle the definition of the jawline is improved, this also re-balances the underlying muscles and provides a ‘lifting’ effect in the neck and jaw area. A well defined jawline with a long neck has been a sign of beauty since the time of the Egyptians. This new procedure which creates a well toned, smooth neck, and raised jawline was named after Queen Nefertiti, whose bone structure continues to be admired in modern times. As a nonsurgical treatment delivered by injection, this also results in a reduction of facial lines and wrinkles. Ashley Pearson from the Daily Mail says It's not your wrinkles but your JAW that is ageing you: Latest Hollywood beauty treatment sees stars having their jowls tightened with the Nefertiti lift How is it beneficial? A Nefertiti Lift can prevent muscles from pulling down lifting the lower face , and return a contoured appearance to your jawline. It helps improved jawline definition and improved appearance of prominent neck bands in a short treatment of time in an effective alternative. Ideal candidates Ideal candidates for the Nefertiti lift are those who are experiencing the initial signs of aging around the jawline and upper neck. Individuals who suffer from more advanced aging in this area may not achieve satisfactory results and may be better suited for a neck and/or chin lift. Patients should also be in good overall health and have realistic expectations for what can be achieved through the procedure. Ideal candidates meet several of the following descriptions: Normal or thin weight No excessive fat along the jawline Loose or folding skin below the chin or jawline Neck bands or “turkey neck” Mild to severe “jowls” or cheeks that hang below the jawline Rippled appearance along the jawline A very pronounced, square jawline Treatment steps Before undergoing the Nefertiti Lift the doctor will examine the lower face and neck to tailor make the treatment for each patient. A numbing cream will be applied 45 minutes before the procedure to decrease the discomfort during the injection. The skin is then prepped and the Botox is gently placed with a very small needle the exact location and depth of placement. Pre Treatment The treatment is suitable for patients of all ages! Younger patients who want to prevent their platysma muscle form becoming overactive and older patients who have high depressor muscle activity which cause facial laxity. Post Treatment Once these muscles are relaxed the net effect is an upward pull from facial muscles, creating a younger looking jawline, neck and face. For a lasting result the treatment can be repeated every 4 months. After care Do not lay your face down before 4 hours after treatment. It’s better to not bend down, lie down, or do strenuous exercise immediately after treatment. Avoiding alcohol ,Aspirin, Ibuprofen or other strong painkillers may reduce the extent of bruising. It’s also a good idea to avoid using a sauna for 2 weeks. To further reduce risk you should avoid aggressive skin manipulation up to one week after treatment. This means try to stay away from treatments or facial massage. Aftercare is incredibly important when it comes to Botox. It’s something that many people overlook. Find out more about this and other Botox treatments at Revival Clinic

Neferititi Lift - Look like the Queen you are!

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The latest anti-aging treatment that tightens the jowls. The Nefertiti neck lift is a new technique where by placing Botox injection along the lower jawline ...

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The Pain related to the treatment The pain associated with BoNT-ONA injections for palmar and plantar hyperhidrosis can deter patients from under- going the procedure. Due to the rich nerve endings in the palms and soles, pain can be significant with the numerous injections needed to achieve the desired effect. In an effort to reduce discomfort from the injection, topical lidocaine cream will be applied. The injection technique With injection sites approximately 8 mm apart. During injection, the needle is inserted at a 45-degree angle approximately 2 mm into the dermis, bevel side up. Once inserted, the syringe is slowly depressed to deposit approximately 0.05 mL of the botulinum toxin solution subdermally before it is withdrawn. A total of 100 U per palm of BoNT-ONA is injected with a 26- or 30- gauge needle and a TB syringe. The BoNT-ONA is diluted in 3 to 4 mL of normal saline and then subdermally injected into each 1-cm square area of the palm and three sites in each digit. Plantar hyperhidrosis presents the same difficulties as palmar. Both regions are particularly sensitive and have a thick epidermis, making topical agents less effective. Given the larger surface area of the soles as compared to the axilla and palmar regions, 150 U of BoNT-ONA is injected through a 26- or 30-gauge needle with a TB syringe following a grid of injection sites (Figure 6). The BoNT-ONA is diluted in 6 to 8 mL of normal saline. Due to the high sensitivity of the area. After Care and Result After the procedure, ice packs are applied while the patient waits in the exam room for 15 minutes to confirm no immediate reaction to the toxin. Curiously, a greater reduction in sweat production often occurs in the nondominant hand after injection. Possible Side effect Muscle weakness is the most commonly published adverse complication. Weakness is noted usually on maximal opposition and is often transient, lasting a few weeks after injection. Reference : Treatment of Hyperhidrosis With Botulinum Toxin Melissa A. Doft, MD; Krista L. Hardy, BS; and Jeffrey A. Ascherman, MD Aesthetic Surgery Journal 32(2) 238–244

Botox for Palmar and Plantar Hyperhidrosis

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The Pain related to the treatment The pain associated with BoNT-ONA injections for palmar and plantar hyperhidrosis can deter patients from under- going the ...

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Our spine, how does it work? The spine is our body’s center support anatomy. It keeps us upright and joins the different parts of our bone to one another: our pelvis, shoulders, head, chest, arms and legs. Even if the spine is built of a chain of skeletons, it is flexible to come from spinal disks and elastic ligaments. [1] Our spine has many features: it supports the weight of your arms, torso, and head, and allows our body to move in every direction. Some parts of the spine are more flexible than other parts. The maximum flexible part is the neck area. The bones that build into the spine also protect our spinal cord, which runs through the spinal canal. The discs work as the shock absorbers between the bones of the spine and are created to help the back stay flexible while resisting tremendous forces in many different planes of motion. Each disc contains two parts: A tough firm outer layer called annulus fibrosus. The outer part of this layer contains nerves. If the disc breaks in this area, it may become pretty painful. A jellylike, softcore called the nucleus pulposus. This part of the disc contains proteins that can provoke other tissues they touch become tender and swollen. If these proteins leak out to the nerves of the outer part of the disc, they can lead to a great deal of pain. Unlike other tissues in our body, the disc has a very small blood supply. Once a disc is damaged, it cannot regenerate itself, and a whorl of degeneration can put in with three stages that seem to happen over 20 to 30 years: Causes of Degenerative Disk Disease Many factors can make discs to degenerate, which include age. Other specific factors, such as: The drying out of the disc. At the time we were born, the disc has about 80 percent water. As we age, the disc dries out and loses their ability to absorb shocks as well. Injuries, which can cause soreness, swelling, and instability. This can occur in low back pain. Sport and daily activity, which create tears in the outer part of the disc. By age 60, most people encounter some degree of spinal disc degeneration. Not everyone at this age experiences back pain, however. Degenerative disc disease, what are the symptoms? The stereotype of a person with degenerative disc disease is an active person, or else healthy and in his or her 30s or 40s. Common symptoms of degenerative disc include: Pain relief while walking or even running than while standing or sitting for long periods. Feeling better, lying down, or changing positions often. Periods of acute pain that come and go. These continue from a few days to a few months before the pain relief. They can range from mild discomfort to severe pain. Pain can trouble the low back, thighs, and buttocks or the neck, related to where the affected disc is, and anxiety can also radiate to the arms and hands. Pain is increased when sitting. When we are seated, the discs of the lower back have triple more load on them than when standing. Pain that gets worse when lifting, twisting, or lifting. Tingling and numbness in the arms and legs. Weakness in the muscle of the leg or foot drop, an early sign of damage to the nerve root. Degenerative Disc Disease Prevention How to take care of your spinal disc health. Keep a good posture – avoid slumping in your chair, crouching over a desk, or standing with your shoulders hunched. Take a short break from sitting every 30 minutes. Avoid sling bags, carry larger loads in a comfortable backpack using both shoulder straps and. Stop smoking – it's believed smoking decrease the blood supply to the discs between the vertebrae, and this may lead to these discs degenerating disease. [3] One of the most effective ways to decrease the chance of back pain is to strengthen your back muscles. Follow these rules to prevent back pain and protect your back : Back-strengthening and stretching exercises such as yoga at a minimum of 2 days a week. Sit and stand up straight. Keep away from heavy lifting. If you do lift something substantial, keep your back straight and bend your knees. Follow this procedure, your leg muscles will manage most of the work. Be active and eat a healthy diet. Being overweight can stress your back. Eating healthy and getting active can help you stay at a healthy weight. [2] Treatment Option for Degenerative Disc Disease Treatment for degenerative disc disease generally starts with noninvasive methods that may give sufficient symptom relief. [3] Nonsurgical Treatment Pain relief strategy focuses on decreasing pain from the damaged disc and helping you back to your routine activities. Methods of pain control such as pain relief medications, electrical stimulation, steroid injections, heat/ice therapy, or back braces. Physical therapy can help strengthen and stretch the back support muscles to let the back heal and decrease the frequency of painful aggravated. Lifestyle modifications, for example, changing your posture, giving up smoking or losing weight, can sometimes help decrease stress on the damaged disc and slow down degeneration progression. Surgical Options Surgical treatment is available for people who experience severe pain or a significant reduction of function and don’t respond well to other types of procedures. The surgery may involve cutting and replacement of either a part or the whole of the affected disc (partial or total disc replacement). Another way is disc removal (discectomy) and fuses the spinal discs together which limited the movement in the damaged spine part. Possible complication from spine surgery Accompanied by any operation, there is the risk of side effects. When surgery is done close to the spinal cord and spine, these complications can be very severe. Complications may involve subsequent pain and disability and the need for correction surgery. You should talk about the difficulties related to operation with your doctor before surgery. The list of complications given here is not a complete list of complications and is not a replacement for discussing the risks and benefits of surgery with your orthopedist. Only your doctor can evaluate your problem and tell you of the dangers of any medical procedure he or she may suggest. [4] Anesthesia side effects: Most spinal surgery requires general anesthesia. A minute number of patients might have problems with this treatment. These could be problems from issues arising from your other medical conditions, reactions to the drugs used, and complications due to the anesthesia. Be sure to talk about these complications with your anesthesiologist. Thrombophlebitis: When blood clots form inside the leg veins, it called Deep Venous Thrombosis (DVT). This is a frequent problem after many types of surgery. Why do we worry about this problem? Blood clots within the deep veins of the legs prevent the normal flow of venous blood from the legs return to the heart. This is one of the reasons why it is better for the prevention of DVT than lets a serious complication happen. Infection: Any time surgery is performed, there always a risk of disease. Anyway, infections happen in less than 1% of spinal surgeries. Hardware Fracture: In many different types of spinal surgery plates, metal screws, and rods are utilized as a part of the surgery to hold the spine in alignment while the wound heals. These metal tools are called "hardware." Once the bone heals, the hardware is generally not doing much of anything. Sometimes before the surgery is completely cured, the equipment can either move - or break from the right position. Known as a "hardware fracture." If this happens, it may need a repeat operation to either replace the hardware or remove the device. Spinal Cord Injury: Any time you do surgery on the spine, there is some risk of damage to the spinal cord. This can cause a severe injury to the nerves or dura part (the covering of the spinal cord). Our spinal cord is a pillar of nerves which joins our brain to the rest of our body, let us control our movements. The nerve fibers in our spinal cord branch off to build pairs of nerve roots that travel along the tiny openings between our spine. The nerves in each part of the spinal cord join to a specific area of our body. Injury to the spinal cord can create disability in particular areas and not others, related to which spinal nerves are injured. Persistent Pain: Some spinal surgery is merely unsuccessful. One of the most common side effects of spinal operation is that it can’t erase all of your pain. In some cases, it might be possible to increase your pain. Be aware of this risk before surgery and talk it at length with your orthopedist. He or she will be able to discuss with you some idea of the likelihood that you may not get the relief that you hope. Sexual Dysfunction: The spinal nerve and spinal cord, sending the nerve signals that allow the entire of your body to function, feel sensation - and even have sex. Injury to the spinal nerve and the spinal cord can create many problems. If a nerve is injured is the one that connects to the pelvic region, it could cause sexual dysfunction. Stem Cells Treatment for Degenerative Disc Disease Cell-Based Therapies and Growth Factors in Lumbar Disc Degeneration. While there are a variety of surgical and invasive options for the treatment of degenerative disc disease, recent attention has been pointing at the reversal and repair of disc degeneration of the affected disc. The various therapeutic method has been tested such as stem cells, biologic growth factors, and gene transplant. While these novel treatment modalities have shown, some promising results consider the reversal of the degenerative cascade. [5] Do patients benefit from intraspinal Stem cell transplantation? A total of 78 mesenchymal stem cell-treated participants were gathered into the six cohort studies with a follow-up time of 6 to 72 months. These participants have shown a mean significant improvement in the Oswestry disability index (ODI) and visual analog scale (VAS) versus the controls (if present). However, this improvement appeared limited to a group of 51 responders (65.4%). In most researches, disc height assessed by MRI did not restore; nevertheless, Pettine et al. (2015) reported an improvement of at least one Pfirrmann grade in eight participants at 12 months MRI follow-up. [8] Possible Complication of Intradiscal Injection Risks of the procedures, like any surgery, these procedures carry some risks: Damage to nearby tissues and nerves Failure to resolve pain Need for further surgery Infection Damage to the disk Intravenous stem cell therapy for the whole-body rejuvenation Unlike the local treatment, systemic stem cell therapy can heal all areas in need at the same time. From the unique property of stem cells called “homecoming,” stem cells will receive the signal sending from the damage and inflame tissue and get to the problem site to repair the damaged tissue and organ. Moreover, systemic stem cell therapy is safe, and when the stem cells are delivered to the body intravenously, non-invasive procedure. References 1. Institute for Quality and Efficiency in Health Care (IQWiG); 2006 Informed Health Care “How does the spine work?” 2. US department of Health and Human Services. Healthfinder.gov.” How to prevent back pain 3. John Hopkins Medicine. Conditions We Treat: Degenerative Disc Disease 4. University of Mary Land Medical Center. Complication of Spine Surgery. 5. Joseph Fernandez-Moure. Novel therapeutic strategies for degenerative disc disease: Review of cell biology and intervertebral disc cell therapy. SAGE Open Medicine Volume 6: 1–11 6. Regenerative Medicine Approaches for Engineering a Human Hair Follicle Gail K. Naughton, in Principles of Regenerative Medicine (Third Edition), 2019 7. Kentaro Yoshida, Placenta Power: For Health and Beauty A useful guide for those seeking placenta-based remedies 8. Markus Loibl1. Controversies in regenerative medicine: Should intervertebral disc degeneration be treated with mesenchymal stem cells? JOR Spine. 2019;2:e1043

Stem cell therapy to treat degenerative disc disease.

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Our spine, how does it work? The spine is our body’s center support anatomy. It keeps us upright and joins the different parts of our bone to one another: ou...

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The Brain Gut Connection If you’ve ever “gone with your gut” to make a decision or felt “butterflies in your stomach” when nervous, you’re likely getting signals from an unexpected source: your second brain. Hidden in the walls of the digestive system, this “brain in your gut” is revolutionizing medicine’s understanding of the links between digestion, mood, health and even the way you think. Scientists call this little brain the enteric nervous system (ENS). And it’s not so little. The ENS is two thin layers of more than 100 million nerve cells lining your gastrointestinal tract from esophagus to rectum. “The enteric nervous system doesn’t seem capable of thought as we know it, but it communicates back and forth with our big brain—with profound results.” The new findings may explain why a higher-than-normal percentage of people with IBS and functional bowel problems develop depression and anxiety, which is important because up to 30 to 40 percent of the population has functional bowel problems at some point.” The Gut: Where Bacteria and Immune System Meet Humans have more bacterial cells—a lot more—than human cells. Bacteria live on the skin, in the nose and ears, and, most of all, in the gut. Until recently, if most people thought about those bacteria at all, we tended to think of them as fairly separate from us. They help with digestion, but otherwise they stay on their side of the intestinal lining, and we stay on our side. But, in fact, there is a lot of interaction between the body’s immune system and bacteria in the gut. Researchers at Johns Hopkins are now in the early stages of figuring out how the composition of the gut changes in different diseases, how the body’s immune system interacts with these tiny hitchhikers and particularly how that relationship may function in disease. “A huge proportion of your immune system is actually in your GI tract,” says Dan Peterson, assistant professor of pathology at the Johns Hopkins University School of Medicine. “The immune system is inside your body, and the bacteria are outside your body.” And yet they interact. For example, certain cells in the lining of the gut spend their lives excreting massive quantities of antibodies into the gut. “That’s what we’re trying to understand—what are the types of antibodies being made, and how is the body trying to control the interaction between ourselves and bacteria on the outside?” Effects of probiotics on gut microbiome Probiotics restore the composition of the gut microbiome and introduce beneficial functions to gut microbial communities, resulting in amelioration or prevention of gut inflammation and other intestinal or systemic disease phenotypes. Proposed mechanisms of probiosis include alterations of composition and function of the human gut microbiome, and corresponding effects on immunity and neurobiology. Increased intestinal permeability and Autoimmune Diseases The intestinal epithelial lining, together with factors secreted from it, forms a barrier that separates the host from the environment. In pathologic conditions, the permeability of the epithelial lining may be compromised allowing the passage of toxins, antigens, and bacteria in the lumen to enter the blood stream. In individuals with a genetic predisposition, a leaky gut may allow environmental factors to enter the body and trigger the initiation and development of autoimmune disease. Growing evidence shows that the gut microbiota is important in supporting the epithelial barrier and therefore plays a key role in the regulation of environmental factors that enter the body. What Causes increased intestinal permeability? The exact cause is a mystery.However, increased intestinal permeability is well known and occurs alongside several chronic diseases, including celiac disease and type 1 diabetes. Zonulin is a protein that regulates tight junctions. Research has shown that higher levels of this protein may loosen tight junctions and increase intestinal permeability. Two factors may stimulate higher zonulin levels — bacteria and gluten.There is consistent evidence that gluten increases intestinal permeability in people with celiac disease.However, research in healthy adults and those with non-celiac gluten sensitivity shows mixed results. While test-tube studies have found that gluten can increase intestinal permeability, human-based studies have not had the same effect.Aside from zonulin, other factors can also increase intestinal permeability.Research shows that higher levels of inflammatory mediators, such as tumor necrosis factor (TNF) and interleukin 13 (IL-13), or the long-term use of non-steroidal anti-inflammatory drugs (NSAIDS), such as aspirin and ibuprofen, may increase intestinal permeability .Furthermore, low levels of healthy gut bacteria may have the same effect. This is called gut dysbiosis. Other Ways to Improve Your Gut Health Take a probiotic supplement: Probiotics contain beneficial bacteria that are naturally present in fermented foods. Taking a probiotic supplement can improve gut health if you don’t get enough probiotics through your diet.Reduce stress: Chronic stress has been shown to harm beneficial gut bacteria. Activities like meditation or yoga can help.Avoid smoking: Cigarette smoke is a risk factor for several bowel conditions and may increase inflammation in the digestive tract. Quitting smoking can raise healthy bacteria numbers and reduce harmful gut bacteria.Sleep more: Lack of sleep can cause poor distribution of healthy gut bacteria, possibly resulting in increased intestinal permeability.Limit alcohol intake: Research has shown that excessive alcohol intake may increase intestinal permeability by interacting with certain proteins The following foods are great options for improving your digestive health. Vegetables: Broccoli, Brussels sprouts, cabbage, arugula, carrots, kale, eggplant, beetroot, Swiss chard, spinach, ginger, mushrooms and zucchini.Roots and tubers: Potatoes, sweet potatoes, yams, carrots, squash and turnips.Fermented vegetables: Kimchi, sauerkraut, tempeh and miso.Fruit: Coconut, grapes, bananas, blueberries, raspberries, strawberries, kiwi, pineapple, oranges, mandarin, lemon, limes, passionfruit and papaya.Sprouted seeds: Chia seeds, flax seeds, sunflower seeds and more.Gluten-free grains: Buckwheat, amaranth, rice (brown and white), sorghum, teff and gluten-free oats.Healthy fats: Avocado, avocado oil, coconut oil and extra virgin olive oil.Fish: Salmon, tuna, herring and other omega-3-rich fish.Meats and eggs: Lean cuts of chicken, beef, lamb, turkey and eggs.Herbs and spices: All herbs and spices.Cultured dairy products: Kefir, yogurt, Greek yogurt and traditional buttermilk.Beverages: Bone broth, teas, coconut milk, nut milk, water and kombucha.Nuts: Raw nuts including peanuts, almonds and nut-based products, such as nut milks. Food to avoid The following list contains foods that may harm healthy gut bacteria.Wheat-based products: Bread, pasta, cereals, wheat flour, couscous, etc.Gluten-containing grains: Barley, rye, bulgur, seitan, triticale and oats.Processed meats: Cold cuts, deli meats, bacon, hot dogs, etc.Baked goods: Cakes, muffins, cookies, pies, pastries and pizza.Snack foods: Crackers, muesli bars, popcorn, pretzels, etc.Junk food: Fast foods, potato chips, sugary cereals, candy bars, etc.Dairy products: Milk, cheeses and ice cream.Refined oils: Canola, sunflower, soybean and safflower oils.Artificial sweeteners: Aspartame, sucralose and saccharin.Sauces: Salad dressings, as well as soy, teriyaki and hoisin sauce.Beverages: Alcohol, carbonated beverages and other sugary drinks. New Gut Understanding Equals New Treatment Opportunities Food Intolerance test Food Intolerance testing in 222 kinds of foods, using only small amount of blood sample. Food Intolerance can be categorised into 2 types; Food allergies and Food intolerance, differentiated by symptomatic periods and types of symptoms, where inflammation, asthma, and edema will be observed instantly after foods taken in patients with food allergy. The allergy can also become a severe case, called “Anaphylaxis,”as it affects the entire body. This particular case is the reaction of body to adulterated substances through Immunoglobulin E or IgE. For food intolerance, it might not occur instantly after food consumption, instead it might take a day for the reaction to start showing. Symptoms of the case include physical abnormality sensation or even long-term health effects. This particular case is the reaction of body to adulterated substances through Immunoglobulin G or IgG. For the case of instant food allergies, patients are required to avoid consuming certain types of foods even in small amount. However, patients with food intolerance are able to consume certain foods that they are allergic to in small amount, differently, up to each individual. Why should we do Food Intolerance Testing? We somehow have no clues on what types of foods we are allergic to. Some of us might only have moderate reactions towards their food allergies, e.g., rash or cough, while some patients witness severe reactions like instant suffocation or even coma. Thus, if we realize the types of foods we are allergic to, we shall conduct our own nutritional planning and avoid consuming certain foods to prevent the risk of allergies. Food intolerance testing with MicroArray technique Using only 5 cc of blood sample for further screening with MicroArray technique to indicate the types of foods we are allergic to. The result will appear in digit form, implying the allergenic foods up to 222 types of foods. It is convenient and fast.The result will return with in a week. Price 25,000 baht More article on The Brain-Gut Connection The Gut: Where Bacteria and Immune System Meet Leaky gut: What is it, and what does it mean for you? Leaky Gut As a Danger Signal for Autoimmune Diseases Front. The Leaky Gut Diet Plan: What to Eat, What to Avoid

The Gut, your second brain!

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The Brain Gut Connection If you’ve ever “gone with your gut” to make a decision or felt “butterflies in your stomach” when nervous, you’re likely getting sig...

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Diabetic neuropathy is nerve damage that can occur in people with diabetes. Different types of nerve damage cause different symptoms. Symptoms can range from pain and numbness in your feet to problems with the functions of your internal organs, such as your heart and bladder. Placenta Extract Anti-inflammation and Repairing Effects Nerve pain can also occur due to inflammation, something which is completely unrelated to pressure from bones or blood vessels.The Anti-inflammatory Function of placenta plays an active role to fix this. Placenta also helps to strengthen the whole body through its Basal Metabolic Function, Immune System Function and Fatigue Recovery Function, boosting the natural healing power of the body. As well as pain arising from specific regions of nerves, pain can also arise due to a stagnation of blood in the limbs or shoulders. Placenta enables blood to flow in the body’s capillaries thanks to its Circulation Function, and is a valuable tool in relieving such pain.

Placenta Extract and Neuropathy

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Diabetic neuropathy is nerve damage that can occur in people with diabetes. Different types of nerve damage cause different symptoms. Symptoms can range from...

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Mesenchymal stem cells (MSCs) are self-renewing multipotent cells that have the capacity to secrete multiple biologic factors that can restore and repair injured tissues. Preclinical and clinical evidence have substantiated the therapeutic benefit of MSCs in various medical conditions. Currently, MSCs are the most commonly used cell-based therapy in clinical trials because of their regenerative effects, ease of isolation, and low immunogenicity. Experimental and clinical studies have provided promising results using MSCs to treat diabetes. This review will summarize the role of MSCs on tissue repair, provide emerging strategies to improve MSC function, and describe how these processes translate to clinical treatments for diabetes. MESENCHYMAL STEM CELLS TO TREAT DIABETES Safety Issue In 2015, investigators from Sweden reported the first study aimed to evaluate safety and efficacy of autologous MSC treatment in newly-diagnosed type 1 diabetics.They concluded that administration of MSCs did not result in adverse events in any of the 10 patients and provided promising C-peptide concentrations at the one-year follow-up. Functional Differences Hu et al conducted a single-center double blind study examining the safety, feasibility, and preliminary outcomes of umbilical cord Wharton’s jelly-derived MSCs for new-onset type I diabetics. The MSC-treated group underwent two intravenous infusions. Postprandial glucose and HbA1c measurements were lower in the experimental cohort between 9 months to 24 months after MSC infusion. Also, insulin usage and fasting C-peptide were significantly improved in the MSC group. A pilot study in China involving placenta-derived MSCs to patients with long-standing diabetes mellitus type 2 revealed the transplantation was safe, easy, and potentially efficacious. This investigation included 10 patients with type 2 diabetes for a duration ≥3 years, insulin dependent (≥0.7 U/kg/day) for at least one year, and poorly controlled glucose. The subjects received on average 1.35 × 106/kg placental stem cells on three separate occasions with one-month intervals between intravenous infusions. Six months after treatment, the insulin dosage and HbA1c measurements for all the patients demonstrated a trend towards improvement. Moreover, C-peptide and insulin release were also higher after MSC treatment. In addition, this study included a group of individuals that translate closer to actual clinical scenarios, as they also had other co-morbidities, including heart disease, kidney disease, and vascular complications. Therapeutic effects of mesenchymal stem cells MSCs STIMULATE TISSUE REPAIR It is well established that the beneficial outcomes of MSCs occur through a paracrine release of biologic factors, rather than engraftment of cells into the recipient tissue. For purposes of this review, studies examining the regenerative properties of MSCs will be generalized into the following major themes: vascular development, anti-inflammation, and anti-fibrosis . Vascular development Angiogenesis, the formation of new blood vessels, is a vital process in tissue wound healing that is a targeted by many pharmacologic agents to treat disorders such as myocardial ischemia, ischemic stroke, and diabetic retinopathy. Preclinical studies in cardiac and brain ischemia support the concept that MSCs improve structural and functional outcomes by repairing and stimulating the growth of blood vessels. The angiogenic properties of MSCs is mediated through the release of hypoxia inducible factor, vascular endothelial growth factor, angiopoietin, and erythropoietin. The ability to repair vascular injury after administration of MSCs has been supported in studies of diabetic peripheral vascular disease, cutaneous wound repair, and bone necrosis . Immunomodulation Although inflammation is the body’s natural response to protect against harmful stimuli, excessive or prolonged inflammatory stress can be detrimental to cells and tissues. For instance, chronic inflammation has now emerged as an important contributor to the pathogenesis of metabolic syndrome. As such, investigators have begun exploring the interactions between inflammation and MSC therapy. In particular, MSCs modulate key inflammatory cell types, including T-cells, natural killer cells, B-cells, and dendritic cells . The MSC interaction with these innate and adaptive immune cells results in down regulation of inflammatory markers (interleukin-1β, tumor necrosis factor α, interleukin-6) as well as an increase in protective cytokines (interleukin-10, prostaglandin E2, indoleamine 2, 3-dioxygenase). Bone degenerative studies treated with MSCs also highlight their ability to decrease the secretion of macrophage inflammatory protein and monocyte chemoattractant protein. In rodent models of acute lung injury, Gupta et al demonstrated that MSCs increase expression of anti-inflammatory cytokine interleukin-10. Anti-Fibrosis Multiple groups have documented the anti-fibrotic effects of MSCs. In a study of radiation-induced pulmonary fibrosis in Sprague Dawley rats, Dong et al showed a decrease in pro-fibrotic transforming growth factor-β and tumor necrosis factor-α after systemic MSC instillation. The authors speculate that MSCs also inhibit lung fibrosis through the secretion of hepatocyte growth factor and prostaglandin. Similarly, a review article of preclinical and clinical studies recapitulates the anti-fibrotic effects of MSCs in liver fibrosis.Taken together, the growing body of literature demonstrates the potential benefits MSCs may offer in endocrine disorders. resource : Therapeutic Potential of Mesenchymal Stem Cells for DiabetesAlvaro Moreir Samuel Kahlenberg and Peter Hornsby

Therapeutic Potential of Mesenchymal Stem Cells for Diabetes

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Mesenchymal stem cells (MSCs) are self-renewing multipotent cells that have the capacity to secrete multiple biologic factors that can restore and repair inj...

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Stem Cell Facial Therapy As we grow older, our natural stem cells gradually and inevitably diminish, along with the ability to reproduce new replacement cells throughout the body including our facial structure. At the epidermal level, skin becomes thinner, more sensitive to irritation, and more prone to wrinkles, freckles, and age spots. Thanks to the uncanny ability of Stem Cell Therapy to repair this damage by reintroducing living, high-quality Stem Cells into the body, this process can be slowed or even reversed. Stem Cell treatments are essentially regarded as a miraculous breakthrough within the medical community, clinically proven to successfully rejuvenate existing cells for more efficient productivity and self-propagation. The aesthetics field, in particular, has successfully applied the use of stem cell in anti-aging treatment procedures to virtually turn back the hands of time with outstanding results. Stem cells are the body's raw materials — cells from which all other cells with specialized functions are generated. Given the right conditions stem cells divide to form more cells called daughter cells. These daughter cells either become new stem cells (known as self-renewal) or become specialized cells (a process called differentiation) with a more specific function, such as blood cells, brain cells, heart muscle cells, or bone cells. No other cell in the body has this natural ability to generate new cell types. At a fundamental level, Live Stem Cell Therapy assists the replacement of old cells with the reproduction of healthy new cells. Using new stems cells recharges the ability to repair older cells within the body or on a recipient area such as on the face and skin. The result in younger looking skin, improved complexion, and brighter skin tone. Are there different types of Stem Cells? Yes, there are several varieties of stem cells. The main differentiation is made based on where the cells come from. Adult Stem Cells (ASCs) As the name suggests these cells come from already formed(adult) tissue but is not about the age of the donor for example newborn babies have ASCs just the same as you and I, in fact they have 10 times more than your average teenager and 100 times more than a middle aged person! ASCs generally already have a specific function and can be divided into 5 groups 1. Hematopoietic Stem Cells (for making blood) 2. Neural Stem Cells (make your brain and nerve cells) 3. Epithelial Stem Cells (these form the 'skin' for you internal organs, etc.) 4. Skin Stem Cells (fairly self-explanatory) 5. Mesenchymal Stem Cells (universal stem cells but more about that later) Pros - no destruction of an embryo - moderate cell division - may have a specific function - can be drawn from the host (autologous) which reduces rejection chances Cons - Not able to create as many daughter cells which means the treatment may fail (not enough cells to succeed) or take too long Embryonic Stem Cells (ESCs) In the first few days after an egg is fertilized, the blastocyst (that will eventually become an embryo and then a baby), is filled with the stem cells that are needed to build a human body. ESCs are drawn from blastocysts that have been created in a laboratory for research purposes, never from a woman's womb! Pros - unlimited cell division - can serve any function (pluripotent) - little chance of rejection Cons - destroys an embryo - may not become the right type of cells - may cause tumors Induced Pluripotent Stem Cells (iPSCs) iPSCs are man-made stem cells, created in a laboratory by genetically reprogramming other cells (like skin cells for example) to act like stem cells. This procedure shows great promise but is still relatively new, only being discovered in 2007. Pros - no destruction of an embryo - unlimited cell division (in theory) - can serve any function (pluripotent) - can be drawn from the host (autologous) which reduces rejection chances Cons - may not become the right type of cells - may cause tumors How can Mesenchymal Stem Cells (MSC) make you look younger? MSC are stem cells which have the remarkable ability to transmute into various types of cells in the body. They are considered universal donor cells, which can be used for transplant into any patient without risk of rejection, and are thus perfectly suited for Cell Therapy treatments. For aesthetic rejuvenation treatment, Mesenchymal Stem Cells (MSC) can act as the initial building blocks for Connective Tissue, which include collagen and elastin, as well for blood vessels and fatty tissue. They can help the skin become more resilient, feel smoother, and appear brighter. Stem cell therapy effects Slows or even reverses visible signs of aging Revives skin cells, lessening fine lines and wrinkles Return of natural moisture to skin Return of resilience and firmness to skin In some cases, blemishes and freckles become less visible Visible results start from 2-4 weeks and become outstanding within 2-3 months after treatment Repeat treatment recommended every year Recovery time 1-3 days Treatment steps Cleanse the face and neck Apply numbness cream for 45 minute to reduce discomfort during the treatment The stem cell will be injected in the specific skin layer all over your face to reverse ageing effect Stem cell therapy for facial after care Avoid direct contact to high temperature for example sauna for 2 weeks Minimal redness and mild swelling can occur and will resolve within 3-5 days, Usually you can resume regular activity the day after treatment Avoid strenuous exercise on the same day with treatment Dr. Chontirot is the founder of Revival Clinic, is experienced in the fields of stem cell science, gene therapy, molecular biology, immunology and clinical research. She is Board Certified and has a background of study with the University of Queensland and Stanford University. Having published articles in numerous medical and scientific forums she can be considered an expert in this field. Revival Clinic’s unique therapies provide a range of successful treatments for a variety of degenerative diseases that include lupus, diabetes, Parkinson's disease, multiple sclerosis, arthritis, and more.

Want a baby face?

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As we grow older, our natural stem cells gradually and inevitably diminish, along with the ability to reproduce new replacement cells.

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Atrophic acne scar: A result of collagen destruction Acne scars are caused by abnormal production and degradation of collagen in the course of the healing process, and result in several types of acne scars. In 80 to 90 percent of cases, there is a net destruction of collagen in the skin that results in an atrophic kind of injury but less frequently, there is a net increase of collagen that results in a raised scar or keloid scars. Type of atrophic acne scar Atrophic scars or indented scars are classified according to the size and depth of collagen destruction; anyway, a different kind of scars is typically seen on the same person, making differentiation difficult. There are three types of atrophic acne scars. Icepick scars - approx. 65 percent of an indented scars. These indentations are narrow, generally smaller than 2 millimeters, V-shaped like, and have a sharp margin that expands down to the deeper skin layer. The depth of these lesions makes icepick scars challenging to fix using standard skin resurfacing options. Boxcar scars approx. 20 percent of indented scars. These scars are more extensive, 1.5-to 4.0 millimeters, oval-to-round depressions with sharply bound steep edges. Shallow boxcar scars (0.1–0.5mm) are manageable to skin resurfacing treatments, although deep boxcar scars (≥0.5mm) are challenging to treat. Rolling scars approx. 15 percent of indented scars. These scars are the widest and may reach up to 5mm in diameter. Fibrous adhesion of the skin and the underlying structure results in superficial shadowing and an undulating appearance of the scars. Acne scar treatment at Revival Clinic Bangkok Since acne scaring usually involves a mixture of scar types, the most effective treatment strategy is multi-modality treatment to answer all types of acne scars. Here is the list of procedures that we use here at Revival Clinic Bangkok. Ice prick scar treatment via TCA cross TCA cross is short for “Trichloroacetic acid chemical reconstruction of skin scars” is a technique using high concentrations of acid (TCA) focally on indented acne scars to induce inflammation followed by new collagen production. This can lead to a decrease in the dept of scars and improve cosmetic appearance. The CROSS technique was the first report by Lee and colleagues. In this technique, a high concentration of trichloroacetic acid is registered focally, by pressing a toothpick-like applicator on the entire indented area of the ice pick scar. Producing a frosted appearance on each scar. Healing is more rapid and related with a low chance of complication rate as the adjacent skin structures are spared. 100% TCA is made to order. We start with a facial cleansing using water and soap to remove oil from the skin. All the ice pick acne scars were marked. Apply the bottom of the injury with 100%. The skin was observed until a ‘frosted’ appearance was seen. The frosting is a result of the protein denature, which is the start of inflammation triggering the new collagen production process. The pain and uncomfortable from this procedure are so minute so no numbness cream or any local anesthesia needed. You may experience mild burning, which was well-tolerated. This was accompanied by frosting, redness and edema, which reduce in 4-6 hours. Crust formation was shown on the next day, which gradually falls off within 3-4 days in most patients depending on their skin type. A sunscreen should strictly use until all crust falls off to prevent post-inflammatory hyper-pigmentation. Makeup can be applied as usual. TCA cross result at revival clinic Bangkok. Eighty percent of our customers show excellent improvement after four sessions and there have never been any severe side effects shown. At the three-month follow-up, the ice prick scar continued to show improvement. Scar resurfacing treatment by micro-needle Skin needling, or collagen induction therapy, is known safe and effective for acne scar treatment by skin resurfacing technique. Not only treat the indented scar but also decrease dark spots from acne. Skin needling is a simple, effective and safe way to manage the indented scar. It did not damage the skin, has short recovery time and creates more skin quality. Skin needling also releases fibrous strands to improve indented cutaneous scars and wrinkles. This method is also useful for skin tightening, rejuvenation and, of course, scar remodeling through improvements in dermal extracellular matrix proteins without causing damage to the epidermis, thus minimizing downtime and limiting side effects. At revival Clinic Bangkok we use sterilized micro-needles to puncture skin superficially, resulting in new collagen production through activating an inflammatory process. Skin micro-needling induces wound healing, in which collagen is formed underneath the skin over 12 to 18 months in the remodeling process. Results of micro-needling treatment for acne scars. There was an outstanding improvement from 400% up to 1000% in collagen and elastin production six months after resurfacing treatment. One year after the therapy, epidermal thickness improves by 40%. The measurement by facial skin analysis showed that the skin roughness had improved one month after treatment. Acne scar resurfacing by fractional laser Laser resurfacing, which eliminates the outer layer of the skin to enhance skin regeneration, has been in use since the mid-1990s. Laser resurfacing also has the effect of heat to improve skin regeneration along with elasticity. Perfectra laser is the latest generation of carbon dioxide fractional lasers, with the combined effects of CO2 laser and fractional technology. A micro-ablative dot of the laser penetrates deep into the skin. Thus severe skin damage is avoided, while lateral thermal damage is decreased, thus reducing downtime and the chances of side effects. Perfectra lasers have a double effect – they encourage renewable processes of the wound and new collagen production as the hyaluronic acid. The results of fractional laser treatment in acne scars are fast and practical. Depending on the scar condition and skin type, it significantly improves the look. About 35% of customers there is a complete removal of scarring and, in another 40%, a significant improvement of scars with nearly all showing a decrease of the lesions. Dotted ice prick and indented scars showed the best response to treatment with fractional laser. Fractional photo thermolysis using fractional perfecta laser is a safe and effective method for treating acne scars. Subcision treatment for acne scar Subcision is a procedure that removes the adhesion tissue, resulting in scar improvement. Furthermore, the induced scar trauma results in blood clot accumulation and new collagen production, which additionally increase scar elevation. Wider, deeper, and more noticeable rolling scars look dramatically better after subcision treatment than they were initially, although boxcar scars improve much less than rolling scars, the procedure is still useful to some degree. Moreover, subcision has shown increased efficiency when used synergistically with other treatment modalities, such as fractional CO2 laser, platelet-rich plasma (PRP). Our clinic treatment produced impressive results in patients with severe acne scar grades 4 and 3. Overall improvement was more than 90 percent of the customer (at least one degree of acne scar improvement) with minimal side effects such as slight redness, edema, and pain lasting for 1-2 weeks. Overall, seventy percent of patients showed an excellent response to the treatment and the procedure was well-tolerated by all customers. Self-extracted growth factor treatment for acne scar The self-extracted growth factor contains the plasma portion of high platelet concentration. Platelets release growth factors and also platelet-derived growth factor plus transforming growth factor-β, facilitating and accelerating soft tissue regeneration. With its regenerative properties, the self-extracted growth factor enhances the response of acne scars to resurfacing treatment and decrease the post-procedure side effects. Multiple mechanisms can explain the synergistic effects of self-extract growth factors on overall clinical improvement. Activated platelets that contain secretory proteins (e.g., platelet-derived growth factor and transforming growth factor) which facilitate chemotaxis and mitogenesis of stem cells, blood vessel formation, and collagen production. The production of hyaluronic acid which can absorb water, increasing skin volume and elasticity, enhance cell regeneration, extracellular matrix, and collagen production. Aftercare for acne scar treatment Use at least 2 grams of sunscreen SPF 30 PA+++ apply several times a day and avoid intense sun exposure directly to prevent post-inflammatory hyperpigmentation. Where possible. Avoid intense sun exposure such as sunbathing for at least one month after treatment. If sun exposure is necessary, wear clothing that covers the treated area. Apply sensitive skin moisturizer (no whitening, No perfume, no AHA, BHA) several times a day for a week. This will enhance skin cell regeneration and minimizing the scab from resurfacing treatment. Do not use abrasive scrubs or toners for a week or so after the last treatment. Allow the skin to fully heal before returning to regular skincare routines. Please read the labels. If your products have any glycolic acids or Retinoic acid in them, discontinue use for two weeks before the procedure and two weeks after the procedure. Cleanse and moisturize daily, with light and mild products. If you have a history of cold sores, please inform your doctor. If you have any questions about aftercare management, please let us know. We are always ready to answer any questions so you can get the best result. Common question and answer about acne scar treatment at Revival Clinic Bangkok My scars are quite severe, but I saw you offered many techniques for correction. I want to get an idea of what would be the recommended procedures? Generally, we use multi-modality in each session (TCA cross, PRP, subcision, fractional laser, micro-needling). This plan works best because the different treatments will take care of all types of scarring; of course, the details of your treatment will depend upon your skin examination. We can discuss the details more during a face to face consultation. Keep in mind there is no obligation or consultation fee. I have resistant acne scarring, what would be the best plan for treatment. The best way in my opinion is First session TCA cross - to correct pitted scar PRP subcision - self-extracted growth factor help stimulate new collagen production Revival Peel - improve shallow acne scar Miracle mask - a decrease inflammation and downtime from the treatment Second session Micro-needling - resurface the whole area make the skin even and smooth fractional laser - for deep pitted scar PRP subcision - self-extracted growth factor help stimulate new collagen production Miracle mask - a decrease inflammation and downtime from the treatment These procedures would be alternated once a month until the desired results are achieved.

Treatments for Acne Scar Removal

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Atrophic acne scar: A result of collagen destruction Acne scars are caused by abnormal production and degradation of collagen in the course of the healing pr...

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The Therapeutic Potential of Mesenchymal Stem Cells (MSCs) You can read more details about the different types of stem cells in our article “The Different Types of Stem Cells“ Cell therapy is the cell transplantation, through local or systemic delivery, of self or other person cells to restore the viability or function of defective tissues. Medical conditions that may potentially be treated with Mesenchymal stem cells include: Degenerative disease (Stem cells for anti-aging) Degenerative disease is a wide range of conditions that result from the wear and tear we all suffer over time; some examples are osteoarthritis, cancer, Alzheimer’s disease, type 2 diabetes, muscular dystrophy, Parkinson’s disease etc. Like the rest of our body, stem cells suffer the adverse effects of aging. Scientists believe that this aging of stem cells which causes a deterioration in their ability to regenerate, repairing, and replace damaged tissue, is one of the leading causes of degenerative disease. Stem cell replacement therapy provides an effective way for the treatment of age-related diseases. A recent study stated, It is believed that the regenerative potential of these cells is due to their high proliferation and differentiation capabilities, paracrine activity, and immune privilege. While most of the bodies stem cell populations remain active throughout our lives in organs deficient of stem cells, stem cell transplantation to replace cells is a promising therapeutic method for functional recovery. This means that stem cells can be used for cell replacement as a treatment intervention aimed at diminishing the effects of aging. Traumatic spinal cord injury with stem cells. The use of mesenchymal stem cells (MSCs) constitutes one of the most important and promising treatment approaches. Their favor, among the other sources and types of stem cells such as embryonic stem cells or IPCCs, increased because of their simplicity of isolation/preservation and their characteristic. The promotion of nerve cells generation or elongation by transplanted neuronal stem cells following damage was reported. Stem cells treatment for cancer recovery. Given their self-renewal and differentiation capacity, stem cells can be used to repair human tissues after chemotherapy. Transplanting HSCs is clinically utilized in many cases to enable lifelong blood cell system recovery after the treatment of cancer with high-dose radiation or chemotherapy. This treatment intends to re-establish bone marrow under marrow failure situation (such as aplastic anemia) and to treat congenital blood cell diseases and works by supplying stem cells that turn into a suitable type of blood cell. Transplantation and successful acceptance of only one HSC can reconstitute blood cells system in recipients. Healthy stem cells derived can theoretically be utilized to repair tumor- or treatment-injured tissues. In regenerative medicine, various tissues can be produced using stem cells. Stem cell therapy may be useful in repairing or replacing cancer patient stem cells. Stem cell stimulation improves stroke recovery. Recent clinical trials of cell therapy have shown cell safety and some effectiveness in reducing after stroke disability. Cell therapy during the short period after stroke was related to stable clinical and imaging outcomes in the InveST and RECOVER studies, while the MASTERS studies shown good clinical effectiveness trends as same as those observed in mouse models. Cell therapy during the stroke period resulted in improved clinical outcomes in both the Sanbio and PISCES studies. The clinical studies reviewed used a variety of different cell types, delivery techniques and delivery locations each delivered with a variable delay from the time of initial stroke event. Even with these differences in trial design, there were no reported cell-related serious adverse event effects. There are many proposed mechanisms by which cell therapy might help improve recovery, which involves immune modulation, enhancement of blood vessel generation, nerve cell generation and production of growth factors and essential substances. Further exploration is needed to learn the specific effects of each type of cell therapy to develop the best combination of cell delivery technique, cell dosing, type of cells used, timing of transplantation, dead tissue area size and location of dead tissue that may benefit from further cell treatment for blood supply restriction type of stroke. More information on stroke recovery is available from BMJ Health Journals Stem cells for skin regeneration following burns. Stem cell treatment can improve the quality of burn wound healing. A recent study suggests it will reduce the formation of scars and re-establish the normal function of the skin and its appendages. Stem cells have the ability of self-renewal and multi-potency. Adult stem cells can produce skin cells. Mesenchymal stem cells can turn into multiple skin cell types and provide wound repair. Labeled MSCs can be observed in the epidermis, hair follicles, sebaceous glands, blood vessels and skin layer in full-thickness wounds. Stem cells treatment for Rheumatoid Arthritis Stem cell treatment might help decrease inflammation and increase the residence of healthy cells in the body. The present-day knowledge of stem cell treatment as a possible treatment for Rheumatoid arthritis. Rheumatoid arthritis causes inflammation in the tissues between joints, which results in a loss of cartilage, the connective tissue that cushions the joints. Over time, cartilage loss can damage the joint and surrounding bone. Mesenchymal stem cells (MSCs) are types of stem cells that be able to develop into bone and cartilage. Synovial MSC therapy means injecting these stem cells directly into the tissues surrounding the damaged joints. Some studies show that Mesenchymal stem cells are also able to suppress the immune system and reduce the body's inflammatory reaction. This makes Mesenchymal stem cell treatment a promising treatment choice for autoimmune conditions such as Rheumatoid arthritis. Heart Disease Regenerative therapies utilize stem cells for the regenerate of heart tissue have been widely used in preclinical and clinical trials during the past 16 years. Induction of new blood vessel synthesis to create new collateral vessels within an area with a lack of blood flow has been in evolution since the mid-1980s, soon after the first trial in human body reports on the blood vessel generation effect of recombinant fibroblast growth factor (FGF). Multiple factors significantly contribute the efficiency of stem cell treatment. Optimal delivery methods are essential for the precise delivery of stem cells to the damaged area of the heart muscle, settlement and differentiation. Among the different techniques, direct injection of cells into heart tissue still calling the most clinical attention. Hearing Loss Preclinical animal trials have shown that mesenchymal stem cells can be a promising new treatment for this problem. These findings have prompted experiments to start human clinical studies to assess the safety and effectiveness of mesenchymal stem cells for the treatment of sensory neuro hearing loss. The objective of the design systematic review is to examine the efficacy of mesenchymal stem cells as a treatment for sensory neuro hearing loss in animal models. Retinal Disease Subretinal use of mesenchymal stem cells repaired degenerating retinas in study of retinal degeneration models in mice. An experimental trial showed that mouse mesenchymal stem cells acquired from culture activated Müller cell (a type of cell in the retina) differentiation and exerted a cell production effect by secreting growth factors. It was also reported in experimental studies that factors secreted from human mesenchymal stem cells prevent light-induced retinal injury. Studies have shown that mesenchymal stem cells can turn into different retinal cell types. Huang et al. reported that mesenchymal stem cells differentiated into retinal pigment -like cells with share morphological characteristic. Parkinson Disease Stem cells have the ability for self-renewal throughout unlimited replication, as same as the capacity to differentiate into any cell type within the body. The capacity to direct the fate of these cells to become a dopaminergic neuron(nerve cell produce dopamine which related to Parkinson’s pathology) possible therefore offers an unlimited number of cells that can be utilized for nerve cell grafting. Stem cell-based therapies are emerging as the most promising method for the development of an appropriate regenerative treatment that could be used in a considerable number of patients. Diabetes The systemic review analysis revealed that the intravenous delivery of mesenchymal stem cells is a better treatment approach for type 1 diabetes than other routes of stem cell treatment. The results of stem cell treatment for type 2 diabetic the average patient age with type two diabetic was 56 years. Stem cell therapy was performed in 11 studies [363 patients with type 2 diabetes]. Stem cell treatment improved the insulin daily necessity levels, as well as hemoglobin A1C, and had a positive effect on other measurable factors. Kidney disease Stem cell-based technology has been bringing us a potentially promising method for treating kidney disease. The mechanism is the kidney protection potential of adult stem cell treatment in experimental models of acute and chronic kidney injury. From different mechanisms at the basis of stem cell-induced kidney repairing. Specifically, cell engraftment, merging into kidney structures, or stem cells producing essential substances for kidney cells. Osteoporosis The utilizing of stem cells for tissue regeneration has raised significant hope in a vast number of medical fields, including musculoskeletal disease. Stem cell treatment for osteoporosis can potentially decrease the chance of fractures and replace lost mineral density by either increasing the numbers or restoring the function of residual stem cells that can multiply and turn into bone-forming cells. Such osteoporosis treatment can be done by the introduction of non-bone marrow origin mesenchymal stem cells (MSCs), typically obtained from bone marrow, umbilical cord blood tissue and fat. Facial skin anti-aging Adipose-derived stem cell [ADSC] and mesenchymal stem cell [MSC] as future anti-aging instruments to some magnitude have provided promising and efficient options in fighting skin and facial skin aging. Moreover, bone marrow-derived mesenchymal stem cells have exhibited a similar ability to repair and rejuvenate aged skin. Stem cell therapy erectile dysfunction in diabetic men The Mesenchymal stem cell is by far the most commonly used cell type in the field of urology and the most favorable method of stem cells delivery in erectile dysfunction therapy is injection stem cell into the shaft of the penis, given its ease of delivery and has proven effectiveness in both preclinical and clinical trials. The regenerative abilities of stem cells are likely achieved by the production of various growth factors into the bloodstream and/or migration of these factors to the major pelvic nerve in addition to cell contact, essential substance signaling system and cellular transformation. The first reported clinical studies of stem cell treatment in diabetic men with erectile dysfunction showed a consistent improvement in penile hardness after a single injection of umbilical cord blood stem cells. While penile hardness was stabled for more than six months. In a different study on the use of stem cells in men with erectile dysfunction after prostate surgery, You showed that injection of bone marrow mononuclear cells seems to be a safe and effective treatment for erectile dysfunction for six months. However, the decline in erectile function over time suggests a need to assess for repeated injections.

What can stem cells really do?

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The Therapeutic Potential of Mesenchymal Stem Cells (MSCs) You can read more details about the different types of stem cells in our article “The Different Ty...

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What are stem cells? Stem cells are distinctive human cells that can develop into many varieties of cell types, from intestine cells to heart cells. In some manifestations, they also have the potential to repair damaged tissues. Importance of Stem Cells. Stem cells are crucial for living things for many purposes. In the 3-5 days old embryo, known as a blastocyst, the inner cells generate the whole body of the organism, which include all of the many specialized cell types and part of the body such as the heart, liver, skin, lung, eggs sperm and other tissues. In some adult tissues, such as the brain , bone marrow, and brain, separate populations of adult stem cells promote replacements for cells that are broken or death through injury, wear and tear, or disease. Given their special regenerative abilities, stem cells offer new potentials for treating diseases such as diabetes, OA knee, and heart disease. There are three types of stem cells: Adult Stem Cells (ASCs) ASCs are un-transform cells found living within specific differentiated tissues in our bodies that can renew themselves or generate brand new cells that can fill up dead or damaged tissue. You may as well see the name “somatic stem cell” used to refer to adult stem cells. The term “somatic” refers to non-progenitive cells in the body (sperms or eggs). ASCs are typically scantly in native tissues, which have rendered them difficult to study and extract for research basics. Occupying most tissues of the human body, discrete populations of ASCs generate cells to put back those that are lost through regular repair, injury, or disease. ASCs are found throughout one’s lifetime in tissues such as the bone marrow, placenta, umbilical cord, gut, skin, fat tissue, brain, muscle, etc. In 1948, the first ASCs were extracted and used in the production of blood. There was an expansion of his procedure in 1968 when the primary adult bone marrow cells were used in clinical treatment for blood disease. Types of Adult Stem Cells: Mesenchymal Stem Cells Neural Stem Cells Skin Stem Cells Epithelial Stem Cells Hematopoietic Stem Cells (Blood Stem Cells) Embryonic Stem Cells (ESCs) Approximately 6 days after fertilization, the embryo (at this stage, called a blastocyst), carries an inner cell mass that is capable of generating all the specialized tissues that are building blocks of the human body. Obtained from the inner cell mass of an embryo that has been fertilized laboratory, ESCs are used for research purposes following informed consent. ESCs are not collected from eggs fertilized in a woman’s body. These pluripotent stem cells, cells that are known to develop into cells and tissues of the three primary germ layers which can become almost any cell type and are only found during the early phase of development. Tumor formation from Embryogenic stem cells. When implanted into immunocompromised mice, human embryonic stem cells (hESCs) give rise to teratoma, a type of tumor made up of several different types of tissue, such as hair, muscle, bone, or teeth. The ability to form teratoma is a requisite typical of pluripotent stem cells. The similarities and differences between adult and embryonic stem cells? Embryonic and adult stem cells each have upside and downside regarding potential use for cell-based regenerative treatment. One of the significant differences between adult and embryonic stem cells is their different potential in the number and varieties of differentiated cell types they can become. Embryonic stem cells can suit all cell types of the body due to pluripotency. Adult stem cells, on the other hand, are thought to be limited to differentiating into divergent cell types of their tissue of beginning. Embryonic stem cells can be grown comparatively quickly in culture. Adult stem cells are rare in fully grown tissues, so isolating these cells from an adult tissue is challenging, and techniques to expand their numbers in cell culture have not yet been worked out. This is an important distinction, as vast numbers of cells are needed for stem cell replacement treatment. Scientists think that tissues derived from embryonic and adult stem cells may differ in the chance of being rejected after transplantation. We don't yet know for sure whether tissues obtain from embryonic stem cells would cause transplant rejection since relatively few clinical studies have tested the safety of transplanted cells received from embryonic stem cells. Adult stem cells and tissues obtained from them are currently assume less likely to initiate rejection after transplantation. This is because a patient's cells could be multiplied in culture, coaxed into taking a specific cell type (differentiation), and then re-implanted into the patient. This use of adult stem cells and tissues obtained from the patient's adult stem cells would mean a significant reduction in the chance that the immune system rejects the cells. This means a considerable advantage, as immune rejection need not be circumvented through the use of immunosuppressive drugs, which may themselves cause unwanted side-effects. Induced Pluripotent Stem Cells (iPSCs) Induced pluripotent stem cells are stem cells that are produced in the laboratory, a middling between adult stem cells and embryonic stem cells. iPSCs are designed through the introduction of embryonic genes into a somatic cell (a skin cell, for example) that cause it to regress to a “stem cell-like” state. These cells, like ESCs, are considered pluripotent but only being discovered in 2007, these man-made stem cells are still a long way from clinical use. In an article from the University of Nebraska Medical Center it was stated, genetic reprogramming to produce embryonic-like cells, is novel and needs many more years of study before use in clinical treatment. The first iPS cells were created by using viruses to insert extra copies of three to four genes known to be essential in embryonic stem cells into the specialized cell. It is not yet totally understood how pluripotency is induced by these three or four “reprogramming” genes, and this question is the focus of ongoing studies. Furthermore, recent studies have focused on alternative methods of reprogramming cells using techniques that are safer for use in clinical settings. THE PROBLEMS OF iPSC - PRODUCTION EFFICIENCY AND APPLICATION SAFETY IN CELL TRANSPLANT THERAPY Since iPSCs come from a genetic reprogramming technique, another serious problem is the gene set itself that is used for the initiation of pluripotency. The abnormal transcription of cancer gene can lead to tumor development from cells derived from iPSCs because of the expression of cancer gene (a gene, which in a specific situation can change a cell into a tumor cell) is associated with the creating of multiple tumors known in oncogenetic. In particular, the overexpression of the cancer gene causes mice outer layer cell change to become cancer, the aberrant expression of Sox2[cancer gene] causes the development of lump and colon carcinomas, breast tumors. Comparison of Different Types of Stem Cells The adult Stem cell in depth There are many adult stem cells, maybe one or more for each tissue of the body. For the sake of brevity, the focus will be on the few that have been widely studied. Neuro-stem cells (NSCs) The neuro-stem cells (NSCs) can turn into a fantastic array of neurons and neural-related cells such as astrocytes and oligodendrocytes. hematopoietic stem cell (HSC) The longest studied and most clinically related adult stem cell is the hematopoietic stem cell (HSC). HAC is a not fully developed cell that can develop into all types of blood cells, including red blood cells, white blood cells, and platelets. Hematopoietic stem cells are found in the systemic blood and the bone marrow. Also called a blood stem cell. Mesenchymal Stem Cells [MSC] A stable, safe, and highly accessible stem cells. Mesenchymal stem cells (MSCs) are adult stem cells that can be extracted from human and animal origin. Human MSCs are the non-hematopoietic, multipotent stem cells with the capacity to become into middle germ cell layer lineage such as adipocytes [fat cell] osteocytes [bone cell], and chondrocytes [cartilage cell] as well neurocytes [nerve cell ] and inner cell layer lineages such as liver cell. Human- MSCs have been cultured multiple times in a specific medium without any severe malformation. Moreover, MSCs have immunomodulatory features, produce cytokines (substances that affect other cells), and immune receptors which regulate the microenvironment in the host tissue. Multilineage potential, balancing immunity, and create of anti-inflammatory molecules makes MSCs a useful tool in the treatment of chronic diseases. MSCs are present not only in fetal tissues but also in specific adult tissues. Efficient populations of MSCs have been found in the bone marrow. Cells which manifests characteristics of MSCs were isolated from amniotic fluid, adipose tissue, amniotic membrane, endometrium, dental tissues, menstrual blood, limb bud, peripheral blood, fetal membrane and placenta, salivary gland, sub-amniotic umbilical cord lining membrane, skin and foreskin, Wharton’s jelly and synovial fluid. Adult Stem Cell properties Through division, stem cells can renew themselves for long periods. All adult stem cells can split into two daughter cells, at least one daughter cell remains as a stem cell. Multipotent: Although still able to change into different cell types, adult stem cells are limited to cells of a particular cell line. The Healer: Adult stem cells are exquisitely reactive to the composite microenvironment in which they introduced. Importantly, in injury microenvironments or implantations, for adult stem cells, the first job is “fixing” the injury before responding to the differentiation requirement of the site or organism. This “sensory” activity is responsive to the phenomenally changing microenvironment of an injury or regenerative site since an injury site goes through essential changes from its start to the final regenerative resolution Cell Dominant: Adult stem cells are the dominant producer in their live-cell activities. In clusters of varieties cells in tissues or at sites of injury, their secretory products control or are commanding in the tissue field related to the other cells Immuno-Modulator: All adult stem cells produce molecules that mainly provide a barrier or protector to inhibit all of the interrogators of the immune system from entering an injury or developmental tissue field. This protector or modulatory activity is the first line of shielding against the establishment of autoimmune conditions. Provider, Stimulator: Adult Stem Cells produce bioactive factors that structure both physically and molecularly the injury or developmental (regenerative) functions. The secreted factors contribute to a progressively and dynamically changing microenvironment that supports regenerative activities (not the maintenance of the innervated muscle). Regenerative: Adult stem cells allow regenerative microenvironments and under the appropriate conditions; the result may be the start of their self-differentiation cascade. Homing: Adult Stem cells have a unique ability to “home in” on sites of tissue injury, damage, or inflammation Adult Stem Cells Regenerative Ability: “The younger, the better “ Adult stem cells, or known as somatic stem cells, are found everywhere in our body in every tissues and organ after development and function as self-renewing cell pools to refill dying cells and regenerate damaged tissues throughout our life. Nevertheless, adult stem cells appear to age with the person. As stem cells age, their functional ability also declines. Specifically, this regenerative ability seems to worsen with age, as injuries in older individuals heal more slowly than in childhood. For instance, healing of a fractured bone takes a much longer time in the elderly than in young individuals. There is a considerable amount of evidence showing that deterioration of adult stem cells in adulthood can become an essential player in the start of several diseases in aging such as coronary heart disease, diabetes, Alzheimer's, osteoarthritis etc. Mesenchymal Stem Cells from the Umbilical cord. Among the adult stem cells, type Mesenchymal stem cells from the umbilical cord are the youngest cell type. Wharton’s jelly mesenchymal stem cells (WJ-MSCs) are a type of stem cells with high differentiative ability, an immuno-privileged condition and easy access for extraction. Umbilical cord stem cells offer dominance character over other types of stem cells as a source of therapeutic cells. First, UCM cells are obtained from a noncontroversial, inexhaustible source, and can be collected noninvasively without surgery at low cost. Second, unlike human embryonic stem cells, umbilical cord stem cells did not cause teratomas[tumor].

The Different Types of Stem Cells

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What are stem cells? Stem cells are distinctive human cells that can develop into many varieties of cell types, from intestine cells to heart cells. In some ...

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Diabetic neuropathy is damage to nerves caused by excess blood sugar, inflammation and blocked small blood vessels associated with diabetes. Left unchecked, diabetic neuropathy can cause complications such as pain and tingling in the hands and feet; it can also result in digestive difficulties and sexual problems. Advanced neuropathy in the feet can lead to the need for amputation of a toe, foot or lower leg. Eating a healthy diet is an important part of managing your diabetes and may help prevent its complications, including diabetic neuropathy. Tight blood sugar management might also help slow the progression of nerve damage. Vitamin Supplements also may play a role in managing diabetic neuropathy What is IV Therapy IV infusion therapy is a method of delivering a high concentration of nutrients directly into the bloodstream to address nutritional deficiency and optimizing health. This process bypasses the digestive system and allows a faster and higher level of absorption with an immediate therapeutic effect. Oral supplements in pill form although beneficial, are largely ineffective in the digestive tract due to poor absorption. IV infusion therapy can be used proactively to help manage chronic health conditions and to optimize health. The benefits are usually experienced instantly by most people Why the drip? Modern lifestyle is becoming ever more demanding with excessive stress, environmental pollution and poor food choices that lead to nutritional deficiency. The depletion of vital vitamins, minerals and amino acids undermines the immune system and can be detrimental to our health, leading to chronic illness. Unlike oral supplements, IV infusions deliver high doses of nutrients directly to the bloodstream allowing for maximum absorption that is safe and most efficient at the cellular level. Is it safe? The intravenous method of delivering a high concentration of nutrients is better tolerated than taken orally. Our IV infusions are specially formulated. The potent ingredients are essential for our cells to function optimally. These vital vitamins and minerals cannot be produced by our body but obtained from our daily food intake. Our modern diet of over processed and fast food, leave us most of the time seriously deficient in these essential nutrients. By supplementing intravenously, we can restore our body back to its peak performance and vitality. The method is just like drawing blood for a lab test. How Vitamin Drip can help Diabetic Neuropathy ? Various nutrients play a role in the protection, repair and function of tissues affected by diabetic neuropathy. So, researchers are interested in nutrition and nutritional supplements to help prevent and manage diabetic neuropathy. Research in this field is still relatively new, and the results of clinical studies have yielded mixed results. However, the following Vitamins have some limited benefit in preventing and managing diabetic neuropathy. Vitamin B-12 Vitamin B-12 is present naturally in some foods. It plays a number of roles in the body, including helping with proper nerve function and red blood cell production.Older adults with or without diabetes — particularly those who follow a vegetarian or vegan diet — have an increased risk of vitamin B-12 deficiency, which may cause neuropathy and other neurological problems. Certain drugs may lead to a B-12 deficiency, including:Metformin (Fortamet, Glucophage, others), a diabetes drugStomach acid-reducing proton pump inhibitors (Prevacid, Prilosec, others)Stomach acid-reducing histamine (H-2) receptor antagonists (Tagament, Pepcid, Zantac, others) Acetyl-L-carnitine Acetyl-L-carnitine is a chemical compound naturally produced in the kidneys and liver. Acetyl-L-carnitine plays an important role in reducing oxidative stress, and it's believed to be involved in nerve cell function and regeneration. A few clinical trials have tested the treatment effect of acetyl-L-carnitine. In these studies, people with diabetic neuropathy had reduced pain, improvements in other sensory problems and improvements in nerve function tests, though these benefits need to be confirmed in additional studies. Some of these studies suggest that the treatment effect is greater when started early in the course of the disease. A healthy diet is essential Although research into the relationship between dietary supplements and diabetic neuropathy is ongoing, eating a healthy diet is widely recognized as a key part of managing your blood sugar and diabetes complications such as diabetic neuropathy.Aim for a healthy-eating plan that's naturally rich in nutrients and low in fat and calories. Healthy meal plans focus on:Vegetables, fruits, legumes and whole grainsFat-free and low-fat dairy productsLean meats, fish, and poultry without the skin Physical activity plays an important role, too Exercise is essential to managing your blood sugar well. Check with your doctor before starting a new physical activity, especially if you're taking medications that lower your blood sugar. People with diabetes should aim for at least 30 minutes of moderate to vigorous activity most days of the week.Drink water before, during and after activity to prevent dehydration. And, be sure to wear comfortable, supportive shoes.

Diabetic Neuropathy, Can IV vitamin drips help ?

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Diabetic neuropathy is damage to nerves caused by excess blood sugar, inflammation and blocked small blood vessels associated with diabetes. Left unchecked, ...

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Like any other part of your body, your skin can be involved in immune responses. Inflammation in the skin often causes a rash to form. What causes skin inflammation? Inflammation occurs when your immune system responds to a stimulus or trigger. There are many different types of cells in the immune system that are involved in inflammation.These cells release a variety of substances that can widen blood vessels and make them more permeable. This allows the immune response to reach the affected area more easily. It also leads to many of the symptoms associated with inflammation, including redness, heat, and swelling. Common inflammatory disease such as Atopic Dermatitis Seborrheic Dermatitis Contact Dermatitis Urticaria Rosacea Placenta Extract the anti-inflammatory and anti-oxidant properties Administration of placental extracts was shown to exhibit anti-inflammatory properties. Amniotic epithelial cells (AEC) and amniotic mesenchymal stromal cells (AMSC) isolated from the amniotic membrane, the innermost layer of the placenta were known to exhibit anti-inflammatory properties. Previous researches by Sur et al. investigated the anti-inflammatory activity of placental extracts by inducing inflammation in the hind paws of Wistar rats with carrageenan, serotonin (5-HT) and prostaglandin E1. Following paw edema inflammation, placental extracts were administered to the rats and paw edema inflammation was reduced significantly. In addition, placental extracts also served as natural anti-oxidants as they contained superoxide dismutase, catalase and glutathione peroxidase which function in neutralizing free radicals, preventing cellular impairment and disease development [67]. Shinde et al.studied the hydroxyl radical scavenging activity, reducing power assay, nitric oxide scavenging assay and anti-lipid peroxidation of human placental extracts and these extracts provide protection and scavenge against various free radicals and are potential source of natural antioxidants. Besides, previous investigation on placental extracts could significantly reduce nitrite-induced oxidative damage in erythrocytes with ABTS scavenging and chelating abilities. The benefit of Placenta Extract for skin The placenta is rich in amino acids, vitamins and minerals, which are necessary for the living body, and it has functions to add moisture to the skin, adjust texture, normalize turnovers and maintain healthy skin. Also it can be used for sensitive skin. Learn more about Placenta Extract click

Placenta Extract treating skin inflammation

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Like any other part of your body, your skin can be involved in immune responses. Inflammation in the skin often causes a rash to form. What causes skin infla...

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Diabetes Mellitus, what is it? Diabetes mellitus (DM), also know simply as diabetes, is a condition that is caused by insufficient secretion of insulin or improperly functioning insulin leading to hyperglycemia as well as severe changes in the metabolic processing of carbohydrates, proteins, and fats. Long term hyperglycemia is known to lead to many serious and often life threatening complications. According to the National Institute of Diabetes, Digestive and Kidney Diseases, "As of 2015, 30.3 million people in the United States, or 9.4 percent of the population, had diabetes. More than 1 in 4 of them didn’t know they had the disease. Diabetes affects 1 in 4 people over the age of 65. About 90-95 percent of cases in adults are type 2 diabetes." Diabetic Mellitus complication Type 2 diabetes can cause serious, potentially life-threatening complications in all parts of the body. These include: Atherosclerosis — Atherosclerosis is a fat buildup in the artery walls, most commonly of the heart, brain, or legs, which impairs blood flow to all the organs. Retinopathy — The rear part of the eye, called the retina, is filled with tiny blood vessels that can be damaged by extended high blood sugar. This damage, in turn, leads to blockages that starve the retina or bleeding into the retina. Both of these situations reduce the ability of the retina to detect light. If diagnosed early, this damage can be minimized by rigorously controlling blood sugar and laser surgery, but if left untreated, retinopathy will lead to blindness. Eye damage - Along with the damage to the retina, diabetes increases the risk of other severe eye diseases, such as cataracts, glaucoma, etc., which potentially lead to blindness. Neuropathy (a.k.a. nerve damage) - This condition typically begins in the extremities with damage to the nerves in the legs (causing pain in the feet) but is also common in arms/hands and can also affect things like digestion, sexual function, and bladder control. Foot problems - Another side effect of neuropathy is that the numbness, may cause a person to not feel irritation in the foot. Of course, the reason our bodies feel irritation or pain is, so we know there is something that needs to be fixed. Without that early warning, sore and blisters may become ulcerous before being noticed. Blood circulation can also be interrupted, leading to reduced healing. This reduced healing also allows small sores or blisters to progress into more dangerous ulcers. If medical intervention cannot reverse these issues, the foot may require amputation. Nephropathy - Diabetics often have high blood pressure as well as high blood sugar, if these conditions are left untreated for an extended period it may lead to severe kidney damage (nephropathy), a disease that damages the small blood vessels in the kidneys. Hearing impairment - People with diabetes are more at risk of developing hearing problems than healthy individuals. Skin conditions - Susceptibility to skin problems, both bacterial and fungal infections, is significantly increased amongst those who have diabetes. Sleep apnea - While obesity may be the main contributing factor to both diabetes and sleep apnea, it has been shown that by treating sleep apnea, you may lower blood pressure and make you feel more rested. Although it's not clear whether it helps improve blood sugar control. Alzheimer's disease - Type 2 diabetes seems to increase the risk of Alzheimer's disease, though it's not clear why. The higher your blood sugar control, the more noticeable the risk appears to be. Treatment option Diabetes Mellitus The backbone of diabetes management is proper diet and regular exercise, which have to be individualized. Both could be the only management needed for controlling blood glucose in type 2 diabetes in its early phase. Patients with type 2 diabetes may require oral hypoglycemic agents or insulin. The treatment plan for diabetes may include diabetes education meal planning and nutritional recommendations exercise anti-diabetic medications insulin management of associated conditions and complications. The care of an individual with diabetes mellitus requires specialists from several healthcare disciplines, including a primary care provider or diabetologist, nutritionist, and a diabetes educator. When the complications arise, various sub-specialists like neurologists, podiatrists, nephrologists, vascular surgeons, cardiologists, and ophthalmologists, are essential. But ultimately, the success of all these specialists is dependent on the patient! On their participation, input, and enthusiasm when it comes to maintaining the strict treatment plans needed to ensure the best possible outcome. Type 2 diabetes is a Disease of Aging Metabolic conditions, including type 2 diabetes mellitus (T2DM) and cardiovascular disease, are strongly related to the aging process. While it is obesity and insulin resistance that are the initial preconditions, it’s among the elderly that the consequences related to metabolic disorders and cardiovascular diseases are frequently found. A decline in lean body mass and an increase in body fat, particularly belly fat that often accompanies aging, may actively contribute to the development of insulin resistance. As for T2DM, it is known that aging induces a decrease of insulin sensitivity and alteration or insufficient compensation of beta-cell functional mass in the face of increasing insulin resistance. When related to beta-cell functions, aging correlates with a decrease of beta-cell proliferation capacity and enhances sensitivity to apoptosis. Recent research has stated, “It has recently been proposed that an age-associated decline in mitochondrial function contributes to insulin resistance in the elderly.” As well as other metabolic diseases also frequently related to aging, such as coronary arterial disease, malignancies, cognitive disorders, and vitamin D deficiency. Stem Cell Therapy Research for the Treatment of Diabetes A review of clinical studies published in the Journal of Molecular Endocrinology discussed the following research about the use of Mesenchymal stem cells (MSCs). In 2011, a pilot study in China involving placenta-derived MSCs to patients with long-standing diabetes mellitus type 2 revealed the transplantation was relatively simple, safe, and potentially productive. This research included ten patients who had been diagnosed with type 2 diabetes for three or more years, insulin-dependent for at least one year, and poorly controlled glucose. The subjects received placental stem cells via IV infusions. After six months of treatment, the insulin dosage and HbA1c measurements for all the patients demonstrated improvement. Also, C-peptide and insulin release were higher after MSC treatment. This study included a group of individuals who, due to other co-morbidities, including heart disease, kidney disease, and vascular complications, more closely matched actual clinical scenarios. In 2013 Hu et al. conducted a single-center double-blind study examining the safety, feasibility, and preliminary outcomes of umbilical cord Wharton’s jelly-derived MSCs for new-onset type I diabetics. The MSC-treated group underwent two intravenous infusions separated four weeks apart. They found significant improvement in all common measurements(insulin dosage, HbA1c, C-peptide, and insulin usage) for the MSC group. The authors concluded that in their research, at least, the transplant of umbilical cord MSCs is feasible and safe. In 2015, investigators from Sweden reported the first study aimed to evaluate the safety and efficacy of autologous MSC treatment in newly-diagnosed type 1 diabetics. Stem cells harvested from the patient’s iliac crest bone marrow did not result in adverse events in any of the ten patients. Lately, researchers have designed insulin-secreting MSCs and delivered them, in combination with hematopoietic stem cells, to patients with type I diabetes. Rather than using donor stem cells, transplanting the patient’s own stem cells via the intra-pancreatic route tended to have improved postprandial glucose and C-peptide measurement in under 24 months. Both studies viewed the stem cell administration as a safe procedure with potential benefits; however, more extensive studies will need to be conducted to substantiate their findings. To Learn More about MSCs visit my past article, How do Stem Cells know where to Repair Stem Cells Treatment for Diabetes Mellitus Recently, stem cell therapy has shown positive results in medical procedures related to the 3Rs (Replacement, Repair, and Regeneration). Of note, 3R treatment uses stem cells and progenitor cells as practical tools to prevent, repair, replace, and treat damaged organs. MSC therapy has been applied successfully in diabetes, from pre-clinical to clinical studies, and is proving to be an excellent platform for diabetes therapy because it can not only slow down the progression of diabetes but also eliminate the complications caused by long-term elevated blood glucose levels. Umbilical Cord MSCs for More Extensive Treatment of Diabetes It has been suggested that MSCs are not merely adult stem able to play many roles cells but also universal donor cells capable of adapting to any host due to their ability to avoid immune rejection. Due to this enormous potential, feasibility to isolate, abundance, and lack of ethical concerns regarding their harvest mesenchymal stem cells (MSCs) have been the cells most commonly evaluated. MSCs are widely distributed throughout the body and can, therefore, be isolated from multiple sources, e.g., the bone marrow, heart, bodily fluids, skin, and perinatal tissues. MSCs react to micro-environmental changes (pH, oxygen, stress) by releasing immune-modulatory and trophic factors known to regenerate damaged cells and tissues. Studies have established that while MSCs can be extracted from both umbilical cord blood and Wharton’s jelly (umbilical cord matrix), advantages to the isolation of MSCs from the Wharton’s jelly (WJ) include higher yield, more homogeneous stem cell population, increased likelihood of successful MSC isolation, and better ability to differentiate into insulin-producing cells. Mesenchymal Stem Cell Transplantation for Diabetes Mellitus MSCs play a vital role in healing damaged tissues; they differentiate and replace the dead cells as well as secrete chemicals needed to activate surrounding cells in the micro-environment, thus improving the tissue repair process. Therefore, MSCs can be applied to treat tissues impaired by chronic hyperglycemia. For Type 1 diabetes(T1DM), MSC transplantation can theoretically increase beta-cell mass through the following actions: beta cell replacement through differentiation (internally or externally); local micro-environment modification by the production of chemicals that stimulate regeneration; reduction or prevention of autoimmune reactions against beta cells. While several MSC transplantation studies have clearly shown the outcome of controlled glucose metabolism, there have also been observations of decreased insulin resistance and enhanced beta-cell function effects. Some studies have hypothesized that the immunomodulatory and inflammatory effects of MSCs are what contribute to the resulting reduction in insulin resistance. by Dr. Chontirot Srikasedsarakul Dr. Chontirot Srikasedsarakul is a specialist in Genomics, Dermatology and Aesthetics.  She has received qualifications from numerous educational institutions like Stanford University, U.S.A.; the University of Queensland, Australia; Chulalongkorn University, Thailand and the American Board of Anti-Aging Medicine.

A New Weapon in the War Against Type 2 Diabetes

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Diabetes is a disease that affects nearly 10% of American's and as such is a modern day epidemic.

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Stem Cells to Fight Ageing? What is a Stem cell? Stem cells are specialized human cells that have the ability to develop into many different cell types, from muscle cells to brain cells. More importantly, they are also able to repair damaged tissues. Stem cells have helped us treat and better understand a range of diseases, injuries, and other health-related conditions. It is accepted that they are beneficial in treating infections of the blood; this therapy has already saved the lives of thousands of children battling leukemia. Also, their value can be seen for tissue grafts to treat diseases or injury to the bone, skin, and surface of the eye. All cells with specialized functions were originally stem cells; in other words, they are the body's raw materials. Under the right conditions, whether in the body or a laboratory, stem cells will divide into what are known as daughter cells. Daughter cells go on to either become new stem cells (renewal of the stem cell population) or become specialized cells (known as differentiation) with a more specific function, such as blood, brain, heart muscle, or bone cells. Stem cells are the only cells in the body with this natural ability to generate new cell types. While the previously mentioned treatments are widely accepted, it is beginning to be understood that cell treatment is useful in a broad range of other medical conditions like, Anti-aging treatment Alzheimer’s Disease Autism and other developmental disorders Cancer immunotherapy COPD and lung disease Diabetes treatment Heart disease Lou Gehrig’s Disease (Amyotrophic Lateral Sclerosis - ALS) Macular Degeneration (AMD) Multiple Sclerosis (MS) Osteoarthritis and other joint conditions Parkinson’s Disease Many detractors are quick to point out that there is, as of yet, little clinical proof of the efficacy of these treatments. But remember Ignaz Semmelweis was ridiculed in the mid-19th century for insisting that doctors wash and disinfect their hands after performing autopsies and that before Louis Pasteur performed his experiments, doctors refused to even believe in the existence of bacteria(germs). So when weighing the pros and cons of stem cell therapy, do not be too quick to accept that a lack of positive evidence equals contrary evidence. All treatments at one stage or another were “new and untested.” And as the so-called anecdotal evidence, from clinics like Revival Clinic and Stem Cells 21, mounts, this supposed lack of positive evidence becomes harder and harder for them to maintain. Aging Stem Cell, Aging Body It is a fact that all cells have half-lives, and their natural expiration must be matched by their replacement to avoid the damages of aging, stem cells seem an excellent source for these new replacement cells. Stem cell depletion and aging-related tissue changes in the human body lead to imbalances in tissue stability and a decrease in our regenerative capacity. These changes often lead to destructive diseases, such as autoimmunity, arthritis, cardiovascular disease, cancer, dementia, depression, neuropathy, obesity, stroke, and tissue degeneration: impaired eyesight and hearing are especially noticeable as symptoms of aging but also a reduction in general muscle and bone strength. Research has shown a definite correlation between the reduction of stem cells found in the bone marrow and the rate at which people recover from bone fractures. The graph below shows clearly how drastic that reduction in stem cells is going from 1 stem cell out of 10,000 cells in a newborn down to 1 stem cell out of 2,000,000 cells in an older adult. The importance of stem cells can not be understated because they play a crucial role in our bodies, from creating our organs while we are still in the womb to maintaining stable bodily function throughout our lives. They also possess the ability to travel all over our bodies and adapt themselves to repair almost any damage they encounter. Tissue-specific stem cells are able to change themselves and replace damaged cells in their specific area, thus playing a crucial role in prolonging tissue function. As stem cells age, though, this ability deteriorates, and they lose their ability to differentiate into various cell types. The loss of stem cell populations and activity over time contributes to age-related disease and becomes a root cause of illnesses like cancer, cardiovascular disease, diabetes, etc. Regenerative medicine can inhibit or even reverse many of these health problems. Through the use of our own stem cells or donor replacement cells derived from a stem or progenitor cell, we can restore or rejuvenate tissue and maintain the stability of our body. Stem cells are useful in treating conditions of the immune system, cardiac tissue, central nerve system, articular cartilage, and skeletal muscle; also, research has shown that stem cell therapy could be used to delay cell death and thus prolong lifespan. Examples of age-related disease Hearing loss Decrease visual acuity Muscle strength and fat loss Decrease Immune function Urologic disorder Cardiovascular disease Hypertension Cancer Osteoarthritis Diabetic Mellitus Osteoporosis Frailty Dementia Depression Aging - the effect on our Nervous system Age-induced reduction in the number of myosatellite cells and neural stem cells undermines nerve regeneration. Which in turn, is associated with the progressive loss of function and can be aggravated by degenerative diseases, such as Alzheimer’s, dementia, Parkinson’s, and stroke. At the cellular level, senescence(cell damage) of the central nervous system is accompanied by several changes that impair nerve function, including elevated levels of oxidative stress and oxidative damage associated with proteins and DNA. It has also been linked to difficulty in cellular energy production and a build-up of harmful substances within the cells. Even without considering the increased chance of disease, we are all well aware of the reduced mental acuity and memory that usually accompanies aging. Where do we get the stem cells from? The two primary strategies for cell replacement involve the transplantation of donor tissue and the internal activation of cell growth. While tissue can be transplanted directly like any other organ transplant, genetically engineered cells that are designed to release substances needed can also be introduced to promote survival and proliferation. The specialized environment of the brain ensures that neural stem cells (NSCs) self-renew and differentiate but mainly enter the neurons. Thus, understanding the characteristics of NSCs and how they are affected by changes in the body could open the door to exploiting their plasticity for the prevention and treatment of degenerative diseases. Why use umbilical cord stem cells? The Healing Oracle team explains, “The umbilical cord fluid is loaded with stem cells. They can treat cancer, blood diseases like anemia, and some immune system disorders, which disrupt your body's ability to defend itself”. This fluid is easily collected and has ten times more stem cells than those obtained from bone marrow. Stem cells from cord blood seldom carry any infectious diseases and are half as likely to be rejected as adult stem cells. Since they are the most primitive cells of the body, they are often referred to as “naive” cells. Thus, where tissue re-growth is needed, they exhibit the adaptability to form the cells of any respective organ. For this reason, the recipient’s immune response is less likely to reject the cells. Stem Cell Replacement as a therapeutic treatment MSCs can be used therapeutically as allogeneic cells(a.k.a. ‘universal cell,’), a cell that can function in any host. To support this suggestion, it was shown that MSCs did not have Major Histocompatibility Complex(MHC) class II cell markers, but only MHC class I and no co-stimulator molecules. Thus, human Stem cells could not be antigen-presenting cells and would be invisible to the host’s immune system. MSCs could differentiate into any number of types of cells, for example, cardiac, muscle, cartilage, etc. So this could be therapeutically useful in the treatment of heart attacks (infarction) where a large number of cardiac cells die (apoptosis) due to the ischemia; the replacement of these expired cells would be expected to provide clinical benefit. How can stem cells help our nervous system? Recent data suggests that stem cell therapy can reactivate damaged nerve cells and thereby promote functional recovery. These reported improvements show that cell therapy is able to replenish lost cells, protect neuron survival, and encourage their regeneration as well as play a role in overcoming permanent paralysis and sensory loss and restoring neurological function. Unfortunately, the definitive reason for these improvements has yet to be identified, but previous research implied that possible mechanisms might include the following: the promotion of blood vessel production, [angiogenesis] increased nerve cell production, [neuronal differentiation and neurogenesis] reduced nerve cell damage, [reactive gliosis] the inhibition of programmed cell death, [apoptosis] the creation of essential peptides and proteins, [expression of neurotrophic factors] control of the immune response, [immunomodulatory functions] and an increase in the ability of nerves to “talk” to each other. [neuronal integration] Inflammation is one of the sources of aging Numerous studies have shown that substances like histamine and serotonin in higher levels are an early warning sign for impending illness or disability in the aging populace. Dr. Calapai says, “Human aging is associated with a vast array of clinical disorders that all relate to the body’s inability to maintain homeostasis. In our bodies, the healing process requires tight control of the acute inflammatory response. When the levels of inflammatory markers such as interleukin-6, tumor necrosis factor-alpha, and C-reactive protein are elevated, there is a direct correlation with several chronic diseases of aging such as cardiovascular disease, cognitive decline, and physical disability.” As Dr. Calapai goes on to say, there is no “cure” for aging, but through the use of various stem cell therapies, we can reduce and control the effects. Mesenchymal stem cells (MSCs) can modulate the inflammation process and aid in the recovery from disease. Many studies, both in animal and human clinical trials, have demonstrated the ability of stem cells to control inflammation. “Therefore, the use of stem cells as anti-aging therapies may offer many an alternative method of slowing down or deterring several of the detrimental aspects of aging.” A healthy habit of supporting your body The other options for the prevention of age-related diseases are well known. We all understand that physical activity, a healthy diet and the removal of bad habits will allow us to live longer, healthier lives. What is good for the heart is generally good for the body as well. The scientific proved healthy habits for the body are Start exercising Eat a healthier diet Take better care of yourself Get more sleep. Manage stress. Stop smoking. Treat underlying conditions. For more information please visit our website Dr. Chontirot is the founder of Revival Clinic, is experienced in the fields of stem cell science, gene therapy, molecular biology, immunology and clinical research. She is Board Certified and has a background of study with the University of Queensland and Stanford University. Having published articles in numerous medical and scientific forums she can be considered an expert in this field. Revival Clinic’s unique therapies provide a range of successful treatments for a variety of degenerative diseases that include lupus, diabetes, Parkinson's disease, multiple sclerosis, arthritis, and more.

Can Stem Cell Therapy Fight Ageing?

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Stem cells are specialized human cells that have the ability to develop into many different cell types, from muscle cells to brain cells.

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The Minor Test Some may administer the Minor’s starch iodine test to determine the location of the sweat glands in the axilla, which provides a template for treatment. In our practice, we rarely apply the starch iodine test; instead, we define the hyperhidrotic area of each axilla according to the hair- bearing area, which is delineated with a marking pen prior to administering a betadine prep. Injection Technique We inject botulinum toxin in the axillary area with a 26- or 30-gauge needle on a TB syringe. In most patients, 40 evenly-distributed injection sites are placed subdermally in each axilla (20 injections per milliliter of injection solution), with the injection sites approximately 8 mm apart. The needle is inserted at a 45-degree angle, approximately 2 mm. The injection should be performed in one smooth motion to reduce trauma to the area. The total injection volume per axilla is 50 U of reconstituted BoNT-A, which was found to be the minimal dose necessary to cause anhidrosis in healthy volunteers.In most patients, these 50 U is diluted in 2 mL of normal saline, but in patients with larger axillae, up to 3 mL is occasionally used to reconstitute 50 U.

Botox for Underarm Hyperhidrosis

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The Minor Test Some may administer the Minor’s starch iodine test to determine the location of the sweat glands in the axilla, which provides a template for ...

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Liver, Why it’s so important? The liver is the largest organ in our bodies, weighing 1.5kg in an adult male, 1.3kg in an adult female, and containing around 250 billion liver cells. It has powerful regenerative abilities, to the extent that even if 60 or 70% of the liver is removed, the remaining 30% will grow back and return it to its original state. The liver is the detoxification center The liver controls most chemical levels in the blood. More than 500 vital functions have been identified with the liver. It also secretes a clear yellow or orange fluid called bile. Bile helps to break down fats, preparing them for further digestion and absorption. All of the blood leaving the stomach and intestines passes through the liver. The liver processes this blood and breaks down chemicals, and creates nutrients for the body to use. It also breaks down (metabolizes) medicines in the blood into forms that are easier for the body to use. [1] Causes of liver damage Infection: Parasites and viruses can infect the liver, causing inflammation that reduces liver function. The viruses that cause liver damage such as Hepatitis A, Hepatitis B, Hepatitis C Immune system abnormality: Diseases in which your immune system attacks certain parts of your body (autoimmune) can affect your liver. Examples of autoimmune liver diseases include: Autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis Genetics: An abnormal gene inherited from one or both of your parents can cause various substances to build up in your liver, resulting in liver damage. Genetic liver diseases include: Hemochromatosis, Hyperoxaluria, and oxalosis Chronic alcohol abuse Fat accumulating in the liver (nonalcoholic fatty liver disease) Medications, herbal supplements, chemicals, solvents are all possible causes of hepatotoxicity.[3] Risk factors of liver damage Factors that may increase your risk of liver damage include: Heavy alcohol use Injecting drugs using shared needles Tattoos or body piercings Blood transfusion before 1992 Exposure to other people's blood and body fluids Unprotected sex Exposure to certain chemicals or toxins Diabetes Obesity What can happens when your liver is damaged? Hepatitis => Cirrhosis of the Liver => Liver Cancer Liver cancer doesn’t happen overnight — chronic liver damage and inflammation-causing liver fibrosis or called cirrhosis which increases the risk of liver cancer. Complications of liver disease vary, depending on the cause of your liver problems. Untreated liver disease may progress to liver failure, a life-threatening condition. Liver disease symptoms Signs and symptoms of liver disease include: Skin and eyes that appear yellowish (jaundice) Abdominal pain and swelling Swelling in the legs and ankles Itchy skin Dark urine color Pale stool color, or bloody or tar-colored stool Chronic fatigue Nausea or vomiting Loss of appetite A tendency to bruise easily [2] How do you keep your liver healthy? Here’s a list of ways to avoid liver disease. Some of them are healthy behaviors you might do anyway. Others may never have occurred to you. Be careful about alcohol consumption If you think only lifelong, falling-down drunks get cirrhosis of the liver — you’re mistaken. Just four ounces a day of hard liquor for men (two for women) can begin to scar your liver. Wash produce and steer clear of toxins Pesticides and other toxins can damage your liver. Read warning labels on the chemicals you use. Prevent hepatitis A, B, and C Get vaccinated: Hepatitis A and B are viral diseases of the liver. While many children have now been immunized, many adults have not. Ask your doctor if you are at risk. Practice safe sex: Hepatitis B and C can develop into chronic conditions that may eventually destroy your liver. They are transmitted by blood and other bodily fluids. Wash your hands: Hepatitis A is spread through contact with contaminated food or water. Watch out for medications and herbs “The number one reason clinical [medicine] trials are stopped, or drugs removed from the market is the liver,” “20 percent of liver injury in the U.S. is caused by supplements.” The National Institutes of Health has a database of substances known to be toxic to your liver. Exercise and eat right: Avoid fatty liver disease by avoiding obesity.[4] The Liver Detoxification IV therapy Vitamin Drip Ingredients used help detoxify the body and promote excretion and liver recovery. As this therapy will help stimulate the functioning of the liver. Protect and Repair your Liver with IV therapy Our Liver Protection Contains: IV Fluids: A sterile saline solution that delivers nutrients directly into your bloodstream, rehydrates your body, and ensures 100% absorption. Glutathione: A highly concentrated dose of glutathione, a powerful antioxidant that provides immune system support, detoxifies your body, removes free radicals, boosts energy levels, and improves neurodegenerative diseases. Amino Acids: Amino acids are a group of organic compounds that form the building blocks of proteins that make up 75% of the body. They are involved in almost everybody's functions, including growth and development, healing and repair, healthy digestion, and providing energy for your body. Vitamin C: Vitamin C is one of the biggest immune system boosters of all. A lack of vitamin C can even make you more prone to getting sick. And also, Vitamin C plays many essential roles throughout your body, helping to maintain systems such as muscles, bones, immune support, and your circulatory system. Multivitamins: Multivitamins help maintain your health and ensure that your body is getting the vitamins and minerals it needs to be working as it should. Placenta Extract: Repair and Protect your liver Human placental extract has been used for decades in China and Japan as a therapeutic agent for liver regeneration and endocrine abnormalities. Placenta extract has been shown to have anti-inflammatory, wound-healing, and antioxidant effects in the clinical setting [6]. Placenta Extract increases natural healing through hormonal regulation, nervous regulation, and immune- regulation, giving the body resistance against disease. We often hear that free radicals cause many modern diseases. It is surprising to learn that the placenta has been confirmed to remove free radicals, adding another form of attack to its ability to strengthen the body. In addition to these functions, the placenta acts to improve basic metabolism, strengthen the liver and counteract toxins, counter inflammation, accelerate the recovery of wounds, accelerate muscle formation, promote circulation, promote blood production, combat allergens, regulate the body, and improve the constitution. MAJOR NUTRIENTS IN THE PLACENTA: Amino acids such as leucine, lysine, valine, threonine, isoleucine, glycine, alanine, and arginine. Active peptides: a key to pharmacological activity. Proteins such as albumin and globulin. Mucopolysaccharides such as hyaluronic acid, and chondroitin. Vitamins such as vitamin B1, B2, B6, B12, C, D, E, and niacin. Minerals such as calcium, sodium, potassium, phosphorus, magnesium, zinc, and iron. Nucleic Acids such as DNA, RNA, and metabolic products. Enzymes: Close to 100 varieties have been found including alkaline and acidic phosphatizing agents. The abundant resource of growth factors Growth Factor has a regenerative effect on cells and organs. The growth factor regenerative effect on the liver was first verified in 1984 by a research team led by Dr. Toshikazu Nakamura at the Osaka University. Later research revealed the effect was not restricted to liver cells and that it prevents necrosis and regenerates almost all organs. A growth factor is a naturally occurring substance capable of stimulating cellular growth, proliferation, healing, and cellular differentiation. Hepatocyte Growth Factor (HGF): Promotes growth of liver parenchymal cells and various tissues. Nerve Growth Factor (NGF): Promotes growth of nerve cells (sensory and sympathetic ganglionic cells). Epidermal Growth Factor (EGF): Promotes growth of skin, lungs, cornea, and tracheal epithelial cells. Fibroblast Growth Factor (FGF): Promotes growth of human fibroblasts, glial cells, and vascular endothelial cells. Insulin-like Growth Factor (IGF): Promotes growth of cartilage cells and smooth muscle cells. Platelet-derived growth factor (PDGF): Promote Wound Healing Growth Factors which Increase Immune Strength - Colony-Stimulating Factor (CSF): Promotes growth of stem cells such as immuno-competent cell granulocytes and macrophages. - Interleukin-1 (IL-1): Promotes production of immune-competent cells (T-cells, B-cells, and NK-cells), thymus cells, and WBC Placenta has a “Hepatocyte Growth Factor,” which acts as a cell and organ regenerator and is considered to be excellent at healing damaged liver cells. The reason that a liver has the miraculous power to grow back even if 70% is removed is because of this Hepatocyte Growth Factor, which protects, repairs, and regenerates liver cells from damage such as inflammation. This is why the placenta is so effective in the treatment of cirrhosis of the liver. The placenta is currently the only medical product approved by the Japanese government for the treatment of cirrhosis. Placenta Extract possesses the following range of functions, which help to prevent liver damage and promote a healthy liver. Boosts the function of the whole liver Improves the liver’s ability to detoxify Increases immune resistance to overcome the Hepatitis virus Strengthens the ability to detoxify alcohol and drugs Promotes self-production of interferons Suppresses alcoholic and viral Hepatitis Supports repair of tissues damaged by Hepatitis, etc Accelerates new cell formation [5] The key to treating liver diseases is to prevent inflammation from manifesting. In order to understand how to live without triggering inflammation, firstly, we need to take a closer look at how liver cells reach an inflamed state. Let’s take viral hepatitis such as Hepatitis B and C as an example. When a virus enters our body, our body’s defense system, or immune system, acts to exterminate the virus. The immune system starts a battle between the immune cells and the viruses, but the primary weapon used by the immune cells is something of a “double-edged sword.” They use active oxygen. While in proper quantities, active oxygen destroys invading viruses, if it is over-produced, it will also destroy the body’s cells. When active oxygen is over-produced in order to combat an unusually active viral infection, it is not the viruses alone but also the surrounding cells and organs which are damaged (oxidized). It is this which produces the inflammation. In other words, Viral Hepatitis is the inflammation of liver cells caused by active oxygen being used by immune cells as a weapon against Hepatitis B and C viruses. If the immune system is in a weakened state, active oxygen is produced in even larger quantities, leaving the body very susceptible to inflammation. Therefore, a robust immune system and the removal of active oxygen are central to the prevention of Viral Hepatitis. One role of the placenta is to protect the fetus from oxidation stress; therefore, it is likely that there is a powerful anti-active oxygen component within the placenta tissue with active oxygen and free radical removal function. After Placenta extract treatment, patients with liver damage regularly see their GOT, GPT values reduced in just one or two months. Placental extract Treatment for fatty liver [7] For more than 40 years, human placental extract (HPE) has been prescribed clinically to treat chronic hepatitis, liver cirrhosis, and other hepatic diseases. In an experimental animal model of hepatitis, HPE reportedly ameliorates hepatic injury through liver regeneration and inhibition of inflammatory reactions and hepatocyte apoptosis. Moreover, recently reported that HPE is effective in NASH patients who were unresponsive to lifestyle. HPE mechanism of treatment HPE treatment enhances endothelial cell survival by increasing anti-apoptotic gene expression HPE treatment ameliorates liver injury HPE treatment damages chronic liver injury In summary, HPE ameliorates the pathology of non-alcoholic steatohepatitis by suppressing inflammation, oxidative stress, and fibrosis. Furthermore, we found that HPE directly contains endothelial cell damage. HPE could thus be an active therapeutic agent with which to suppress progression from simple fatty liver to non-alcoholic steatohepatitis. References: 1. John Hopkins Medicine. https://www.hopkinsmedicine.org/ Liver anatomy and function 2. Mayo clinic staff. Mayoclinic.org “liver disease “ 3. Medically reviewed by Saurabh Sethi, MD, MPH on May 30, 2019 — Written by the Healthline Editorial Team and Heather Cruickshank. Healthline. Everything you need to know about fatty liver 4. John Hopkins Medicine. https://www.hopkinsmedicine.org/ . 5 ways to be kind to your liver 5. Kentaro Yoshida, Placenta Power: For Health and Beauty A useful guide for those seeking placenta-based remedies 6. Regenerative Medicine Approaches for Engineering a Human Hair Follicle Gail K. Naughton, in Principles of Regenerative Medicine (Third Edition), 2019 7. Akihiro Yamauchi ,Placental extract ameliorates non-alcoholic steatohepatitis (NASH) by exerting protective effects on endothelial cells

Liver Detoxification

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Liver, Why it’s so important? The liver is the largest organ in our bodies, weighing 1.5kg in an adult male, 1.3kg in an adult female, and containing around ...

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What Is Osteoarthritis? Osteoarthritis(OA) is a condition in which the cartilage (natural cushioning between joints) wears off. When this occurs, the bony part component of the joint rubbing more and more against each other as a consequence of decreasing cartilage, the shock-absorbing part. This rubbing creates in pain, stiffness, swelling, reduce the ability to move and also sometimes the formation of bony projection along the bone edges. Symptoms Loss of flexibility. You may not be able to mobilize your joint throughout its full range of motion. Grating sensation. You may experience a grinding feeling when you exert the joint, and you may hear crackling or popping. Abnormal bone growth. Bone spurs are the extra bits of bone, which perceive like hard mass, can form surround the affected joint. Swelling. This is caused by the inflammation of soft tissue around the joint. Pain. Affected joints may become painful after or during movement. Stiffness. Joint stiffness may be most detectable upon awakening or after being immobile for an extended period. Tenderness. Your joint may feel painful when you press a light pressure to or near the joint. What causes OA of the knee? Osteoarthritis has a multiple constituent etiology, which come from the influence of local and systemic factors. Osteoarthritis happens in all ages. The theory is that particular genes are responsible for this disease. Obesity, sports participation, genetic susceptibility, and injury to the joint predispose young athletes to the progress of premature osteoarthritis. History of knee trauma multiplies the risk of knee osteoarthritis 3.86 times. Female gender, Old age, obesity and overweight, knee injury, bone density, repetitive use of joints, joint laxity and muscle weakness, all play roles in the development of joint osteoarthritis. Factors that increase the risk of knee OA Age Trauma Muscle weakness Joint laxity Mechanical forces Repetitive knee trauma Kneeling Squatting Meniscal injuries Genetic susceptibility Obesity Female gender How to prevent OA in the knee? Several risk factors might put a person at risk of developing osteoarthritis and while making changes may not reverse the condition, a person may be able to decrease their risk or slow the progression of osteoarthritis. Keep your healthful weight: Excess weight puts more pressure on the knees. Over time, this gives to wearing down the cartilage. Excess fat can also induce the body to secrete cytokines, a type of protein. This can lead to extensive inflammation, and it can turn the way that cartilage cells work. Managing blood sugar: High blood sugar levels can influence the structure and function of cartilage, and diabetes increases the risk of cartilage loss and inflammation. Regular exercise: Moderate to intense activity can keep the joints stay flexible, strengthen the muscles that hold up the knees, and decrease the risk of varieties health problems. It may help to walk, gardener, swim for 30 minutes at a time, five times per week. Everybody who has not exercised for an extended period, possibly due to hard with mobility, should ask a medical professional for recommendations about how to start. Reducing the injury risk: Cartilage that persisting damage from a repetitive injury is more prone to develop osteoarthritis later. It would be better to decrease the risk of slipping in the house by wearing shoes that fit well and use protecting equipment while playing sports to save injury. Keep away from overuse: Some sports or professions related to repetitive movement of the knee joint, such as squatting or kneeling. People who usually lift more than 25kg might have an increased risk of osteoarthritis. Jobs that set people at risk, such as unloading trucks or ships and laying carpets. Varying activities and getting adequate rest intervals of work or exercise might help. Treatment options for OA knee damage Osteoarthritis is a degenerative and progressive problem, with the damaged structure is unlikely to revert and repair. So, current treatment modalities are targeted towards symptom management until the degree of severity dictates the necessity of surgical treatment with joint replacemen Rehabilitation: There are different treatment options for osteoarthritis, for example, occupational, physical and alternative therapies. * Physical therapy uses exercises to strengthen muscles and enhance flexibility and joint mobility. * Occupational therapy targets helping you better cope with your normal activities and lifestyle, for example, getting dressed, walking, and bathing. You may only need these treatments for a short period as you learn to manage with your osteoarthritis or as your symptoms exacerbate. * Alternative treatments for osteoarthritis can include massage, relaxation therapies, and hydrotherapy. Acupuncture may also be useful. That acupuncture may be effective in decreasing osteoarthritis symptoms when used with additional medicines or, in some scenarios, in place of pain medication together. Medication: Many patients with osteoarthritis take medications to reduce pain and symptoms, such as: * Acetaminophen This is frequently the first-line treatment for those with mild-to-moderate osteoarthritis pain. Common side effects such as upper stomach pain and nausea. * Nonsteroidal anti-inflammatory drugs (NSAIDs). If acetaminophen can’t provide relief, you may consider a Nonsteroidal anti-inflammatory medication, for example, ibuprofen or naproxen. These over the counter medicines can sometimes generate stomach problems. Supplement with hyaluronic acid: Hyaluronic acid (HA) is a natural glycosaminoglycan produced by intra-articular cells that synthesis joint lubrication fluid. It provides viscous lubrication, has shocking absorbing features and additionally, possible anti-oxidant and anti-inflammatory functions have been reported. The current proof regarding effectiveness is conflicting Intra-articular injection treatment choices for knee osteoarthritis: * steroid injections: steroids can suppress the immune response and interrupting the inflammatory cascade at multiple levels. It is believed that these are some of the processes of increase joint mobility and pain relief in knee osteoarthritis. * Intra-articular hyaluronic acid for the knee: Tend to be less beneficial than those for steroid injections. The 2013 American Academy of Orthopedic Surgeon guidelines strongly recommends against the use of hyaluronic acid for the treatment of symptomatic knees. Cellular therapies for treatment of OA knee damage offered at Revival Clinic Placenta Extract Human placental extract has been used for decades in Japan and China as a treatment agent for liver endocrine abnormalities and regeneration. Placenta extract has been proven to have wound-healing, anti-inflammatory, and antioxidant effects in the clinical trial [6]. Placenta Extract enhances natural healing through nervous regulation, hormonal regulation, and immune- regulation, giving the body resistance toward disease. Placenta Extract carries a variety of nutrients, growth factors, and anti-oxidants. For more details visit our website HERE Osteoarthritis is an inflammation which rises because of degeneration (deformation) of the joints. When bones aging, this cartilage can be punctured or wear out, and the pain of two bones directly rubbing against each other is the symptoms of osteoarthritis. The condition can go undetectable or if it isn’t very severe, often with bouts of sudden pain. Placenta extract can be used to treat osteoarthritis successfully. While the placenta’s anti-inflammatory function can work against the pain, its tissue repair ability promotes regeneration of the damaged tissues. Another avenue of attack is its “insulin-like growth factor,” which enhances the growth of smooth muscle cells and cartilage and is remarkably efficient at treating and preventing osteoarthritis. Professor Kazuhito Asano and his team at Showa University’s Medicine Department described that high levels of active oxygen were observed in the joints of sufferers of osteoarthritis and rheumatoid arthritis, this is likely to be a cause of degeneration and pain. Asano’s group found active oxygen in the joints of 40 osteoarthritis patients and 19 rheumatoid arthritis patients who visited their university hospital and detected no active oxygen in the joints of healthy people. The severity of the symptoms in each patient were graded into four levels, and the levels of active oxygen were, on average, 2.5 times higher in the case of osteoarthritis patients and five times in the case of rheumatoid arthritis patients. They concluded that active oxygen was damaging the tissues in the joints and causing the condition to degenerate. Placenta extract has demonstrated an ability to eliminate active oxygen; hence it can play this additional beneficial role in rheumatoid arthritis and osteoarthritis treatment. [10] Stem Cell Therapy Stem cell treatment for knees is minimally invasive. It’s a way that can decrease inflammation, repair, and slow all these types of damage from joint inflammation, and prevent or delay knee replacement surgery. In the study, each patient was injected in a single knee. The natural deterioration of the knee continued in the other knee, at five years, those knees that were injected with stem cells were in better shape than they were before the injections. How does stem cell treatment fix the knee? Researchers suggest that stem cell therapy for the knee works by: Developing into essential cartilage cells Produce proteins called cytokines that slow degeneration of cartilage and reduce pain Prevent the inflammation that can worsen arthritis How effective is stem cell therapy for the knee? Researchers from the Krembil Research Institute in Toronto, Canada, recently examined the beneficial use of stem cells to treat knee osteoarthritis. They reported their results in the journal STEM CELLS Translational Medicine. The researchers wanted to know whether it may be possible to regenerate and repair knee cartilage using mesenchymal stromal cells (MSCs). These cells can develop into various cell types, including bone, muscle, and importantly, cartilage. In all, the researchers recruited 12 patients with moderate-to-severe knee osteoarthritis and extracted mesenchymal stem cells from each person's bone marrow. In this study, one of the main goals was to establish what constituted a safe and effective dosage, so the researchers injected each patient with one of three different doses of MSCs. Twelve months after treatment, the researcher followed the patient, assessing their progress. For instance, they measured the inflammatory biomarkers level and the cartilage breakdown rate, and they check regular MRI scans of the affected joints. They also asked the patients to rate how well they believed they were doing. By the end of the year-long study, the researcher found that there was a significant increase in quality of life and a decrease in pain. There was a significant decrease in inflammation within the knee joints of the patients, which is crucial because experts now believe inflammation to be a key driver of osteoarthritis. Known side-effects of stem cell treatments for the knee Stem cell therapy for knees is noninvasive and seldom painful. Side effects, if any, are minimal and rarely rise above as mild pain or swelling at the injection site. For more information please visit our website HERE Frequently asked questions about stem cell treatment at Revival Clinic. Where are your stem cells from? The stem cell that we use is Mesenchymal stem cell from a human umbilical cord. The lab that we partner with cultures MSCs with all Zeno free medium (The most expensive medium on the market). This laboratory is fully ISO certified and utilizes a state of the art class 100 cleanroom (a controlled environment where injectable drugs are manufactured). Every patient receives a certificate showing full details of the stem cells that we used for their treatment. Who conducts the procedure? While the doctors at Revival clinic are fully qualified and internationally trained to administer stem cell therapy, due to the sensitive nature of joint treatments, the actual injection will be conducted by the orthopedic surgeon. How effective are your stem cells? Mesenchymal stem cells (MSCs) have been successfully employed to resurface the degenerated cartilage. Intra-articular (IA) administration of MSCs leads to pain reduction and cartilage protection or healing. The pain reduction and improvement in function will start to be seen within no more than a month and these improvements will gradually increase over time. The rate of repair varies among individuals based on many factors. The better your general health is, the more likely you are to have a faster response. We do a full review of patient progress each year when treating knee arthritis. And have found that all customers have attended more than 50% improvement in both pain and function. Of our past clients, 100% recommend people who have arthritis should seek this treatment. Do you use anesthesia for the treatment? To inject stem cells into the knee, we use local anesthesia only to minimize any discomfort that may be felt.

Arthritis in the knee is truly crippling!

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What Is Osteoarthritis? Osteoarthritis(OA) is a condition in which the cartilage (natural cushioning between joints) wears off. When this occurs, the bony pa...

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Regenerative Medicine On 7th January, 2001, Asahi Shimbun, a Japanese newspaper, carried the sensational headline, “Cell Regeneration Drug to Begin Clinical Use”. The article discussed the start of treatment using Hepatocyte Growth Factor (HGF), which has a regenerative effect on cells and organs. It declared that the treatment would revolutionise 21st century medicine. HGF’s regenerative effect on the liver was first verified in 1984 by a research team led by Dr. Toshikazu Nakamura at the Osaka University Graduate School of Medicine’s Biomedical Research Center. Later research revealed the effect was not restricted to liver cells and that it prevents necrosis and regenerates almost all organs. Animal testing revealed that “HGF repairs untreatable serious illnesses of the liver and kidneys, heart, blood vessels, and nervous system”. Animals were infected for the purpose the experiment, and when HGF was injected a wondrous effect was observed whereby cells on the verge of death were revived. Thus, animal testing showed it to be effective for almost all diseases except for cancer. It was such an amazing result that people began to refer to HGF as the “Happy Growth Factor”. Major Diseases which HGF was effective against in animal testing Liver Diseases: acute hepatitis, hepatitis, cirrhosis of the liver, and liver transplantation. Kidney Diseases: renal failure, kidney transplantation. Lung Diseases: acute pneumonia, and lung fibrosis. Digestive Diseases: gastric ulcers, and diabetes (pancreatic cell regeneration). Cardiovascular Diseases: heart attack, cardiomyopathy, obstructive arteriosclerosis, and prevention of coronary stenosis. Muscular Diseases: muscular dystrophy. Cranial Nerve Diseases: stroke, Parkinson’s Disease, and Lou Gehrig's disease. (Asahi Shimbun, 7th January, 2001) So at last, clinical trials began in earnest to look into whether it would also be effective for humans. Plans for trials are in progress at Osaka University for obstructive arteriosclerosis and heart attack patients and at Hyogo College of Medicine for cirrhosis of the liver sufferers. Nonetheless, thorough data must be accumulated on both effectiveness and safety before this research can be considered as practical treatment, so it is expected to take a little more time. However, careful readers will have noticed a wonderful thing. Look again at the previous section on Growth Factors and you’ll see that HGF is present in placenta. We can make use of the amazing power of HGF, the Happy Growth Factor, right now by using placenta. Discovery of Metastin which Suppresses Progression of Cancer Cells The wide range of diseases which can be treated using Placenta Extract will be described later, but below is a press release regarding one particular breakthrough. New Bioactive Peptide “Metastin” discovered,which suppresses the spread of cancer As a result of research into orphan receptors, Takeda has discovered a bioactive peptide which shows a cancer suppressant effect. The peptide is created by the cancer suppressant gene “KiSS-1”, and it has been named “Metastin” after the word “metastasis”, meaning the spread of cancer. Our pioneering first research facility discovered four new peptides called PrRP, Apelin, GALP, and RF amide, during research into orphan receptors. They were found to be receptors for the bioactive peptides MCH, Urotensin II, and Neuromedin U. Animal testing at our second medical science facility has already produced a report in March to the Pharmaceutical Society of Japan that the MCH antagonist shows an anti-obesity function. The discovery of Metastin is a further result of this continuing research into orphan receptors. In the current research, ligand peptides of the orphan receptor 0T7T175 are isolated and purified, and found to be a new peptide produced by the KiSS-1 cancer suppressant gene. Gene KiSS-1 was reported on in 1997 by a research group led by Professor Welch at Pennsylvania State University, but only now have the products and functions of this gene been demonstrated. An experiment was carried out whereby a variety of melanoma in mice was injected subcutaneously, and a tumour allowed to form for five weeks before being transferred to the lungs. There the Metastin receptor 0T7T175 was artificially produced. The spread of the melanoma to the lungs was found to be suppressed significantly by the continuous administering of Metastin. Additionally, in test tube experiments Metastin was confirmed to suppress both migrational response and nociceptive response. This indicates that Metastin inhibits the ability of cells to move, which would explain the cancer suppressant effect within the body. Further investigation will be required to determine whether Metastin has a similar cancer suppressant effect on human cancer cells, however it is hoped that Metastin will suppress the spread of cancer in ovarian cancer cases, as this has a relatively high frequency of Metastin receptors. Metastin is also present in human placenta in large quantities, suggesting that it’s likely that the placenta plays a major physiological role. Initially, we believe that a sustained release and low molecular weight compound of Metastin should be explored with a view to application as a cancer suppressant. Details of this research were published in Nature on 31st May, 2001. Takeda Pharmaceutical Company Limited 31st May, 2001 Cancer Suppressant “Metastin” Discovered in Human Placenta Takeda Pharmaceuticals announced yesterday they have discovered a bodily substance which suppresses the spread of cancer, naming it “Metastin”. The gene which produces Metastin was also found. The research was published yesterday in the magazine “Nature”. The company hopes to explain the link between the cancer drug and the spreading process. Metastin exists within the body as peptides which can be connected to amino acids. The Takeda research team discovered Metastin in the human placenta. While investigating the arrangement of such amino acids, they found Metastin was produced by the “KiSS-1” gene, which is a known skin cancer suppressant. KiSS-1 was discovered by researchers in the USA in 1997, but it was not known until now that it produced Metastin. In an experiment where skin cancer was introduced to the lungs of mice, Metastin reduced the spread of the cancer by approximately one third. Asahi Shimbun, 1st June, 2001 Cancer Suppressing Material Found in Placenta Proteins A new peptide has been found which forms inside the placenta when a certain “receptor” is attached to the cell. The KiSS-1 gene, which suppresses the spread of cancer, was already known, but a new protein named Metastin was discovered which is produced by this gene. In experiments, skin cancer cells in mice were transferred to the lungs, but when Metastin was administered its spread was greatly suppressed. Nikkei Shimbun, 1st June, 2001 * Articles about the discovery of a substance which suppresses the spread of cancer appeared in both the Asahi Shimbun and the Nikkei Shimbun on 1st June, 2001. This substance exists in large quantities in the placenta. It seems likely that further such substances are just waiting to be discovered in the placenta. The Medicinal Properties of the Placenta Many researchers have found that the placenta possesses a variety of medicinal effects, just like in the articles above. When you consider the many nutritional properties and growth factors of the placenta, the “all-purpose organ” seems quite an appropriate description. Main Medicinal Functions of the Placenta Nervous System Regulatory Function (specifically the autonomous nervous system) Endocrine (Hormonal) System Regulatory Function Immune System Function (raises resistance to illness) Basal Metabolism Function (energises the metabolism, activating cells, blood vessels and organs) Active Oxygen Removal Function (prevents oxidation) Anti-inflammatory Function Tissue Repair Function Tranquillising Function It has also been shown to have a number of other functions as follows. Anti-toxin Function (strengthens the liver) Lactation Promotion Function Anti-Allergy Function Constitution Function Circulation Function Blood Production Function Anti-mutagen Function (suppresses mutations) Blood Pressure Regulatory Function Fatigue Recovery Function In addition, the following have been reported by many doctors, as diseases which placenta is effective against. It is clear that the key feature of the placenta is applicability to such a wide variety of conditions. This means that when you treat an illness with placenta it isn’t just one illness which is improved, but there are often other general improvements in health and beauty such as waking up refreshed, feeling less tired, or having clearer skin. Placenta Can Treat the Following Conditions Gynaecology: menopausal disorders, menstrual pain, irregular menstruation, failure of lactation, and high prolactin levels, etc. Internal Medicine: hepatitis, cirrhosis of the liver, chronic pancreatitis, diabetes, chronic gastritis, dyspepsia, gastric ulcers, duodenal ulcer, ulcerative colitis, bronchial asthma, chronic bronchitis, high blood pressure, low blood pressure, habitual constipation, and collagen disease, etc. Surgery: chronic rheumatoid arthritis, osteoarthritis, arthritis, neuralgia, lumbago, and stiff shoulders, etc. Dermatology: atopic skin complaints, psoriasis, body odour, eczema, chapped skin, spots, and freckles, etc. Psychiatry: autonomic ataxia, and sleeplessness, etc. Urology: enlarged prostate, cystitis, and haemorrhoids, etc. Ophthalmology: cataracts, allergic conjunctivitis, and vision loss, etc. Ear, Nose and Throat: allergic rhinitis, Meniere's disease, and hay fever, etc. Dentistry: pyorrhoea, and gum disease, etc. Other: fatigue, chills, weak constitution, recovery of strength during and after illness, muscularity, and strength of mind, etc. Effective Use of Placenta for Health and Beauty Essentially, the placenta is a temporary organ formed to develop the embryo and is expelled after birth. In most mammals other than humans the mother actually eats the placenta after birth. You may have noticed that when a cat or a dog gives birth, the placenta is left with the mother and child. Even herbivores like cows and horses are known to eat the placenta. Some reports have it that this is to hide the smell of birthing to protect the young from predators, but a more likely explanation is that the mother recovers strength after the delivery by eating the nutrition-rich placenta. The lactation promotion function is an additional reason. There is a great deal of wisdom in the habits of animals. Until recently, the tradition in Japan was to use the placenta and umbilical cordas an offering on an altar, to pray for the growth of the child. However, in earlier times when medicines were scarce, if a child became very ill the umbilical cord would be ground into a powder, boiled, and administered as a special medicine. Source : Placenta Power: For Health and Beauty A useful guide for those seeking placenta-based remedies Kentaro Yoshida Director of the Yoshida Clinic

Placenta Extract can treat so many conditions!

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Regenerative Medicine On 7th January, 2001, Asahi Shimbun, a Japanese newspaper, carried the sensational headline, “Cell Regeneration Drug to Begin Clinical ...

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